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Churc1 churchill domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 211151, updated on 2-Nov-2024

Summary

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Official Symbol
Churc1provided by MGI
Official Full Name
churchill domain containing 1provided by MGI
Primary source
MGI:MGI:1923684
See related
Ensembl:ENSMUSG00000090258 AllianceGenome:MGI:1923684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
chch; My015; 1700030P15Rik
Summary
Predicted to enable DNA binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within mesoderm development and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in brain; cranial ganglion; and dorsal root ganglion. Orthologous to human CHURC1 (churchill domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 32.2), heart adult (RPKM 23.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Churc1 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76812312..76829954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76765538..76783180)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7148 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 3 Neighboring gene expressed sequence AI463170 Neighboring gene STARR-seq mESC enhancer starr_32529 Neighboring gene STARR-seq mESC enhancer starr_32530 Neighboring gene STARR-positive B cell enhancer ABC_E8490 Neighboring gene spectrin beta, erythrocytic Neighboring gene STARR-seq mESC enhancer starr_32532 Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene predicted gene, 34988

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Sheng G, et al. Cell, 2003 Nov 26. PMID 14651851
  2. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • 1700030P15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
protein Churchill

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206534.2 → NP_996257.1  protein Churchill

    See identical proteins and their annotated locations for NP_996257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC132331, BC076499
    Consensus CDS
    CCDS36478.1
    UniProtKB/Swiss-Prot
    Q6DG52, Q8VCP1
    Related
    ENSMUSP00000047015.8, ENSMUST00000041262.14
    Conserved Domains (1) summary
    pfam06573
    Location:1 → 111
    Churchill; Churchill protein

RNA

  1. NR_154884.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC132331, BC076499, BQ044298, BY089267
    Related
    ENSMUST00000126408.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76812312..76829954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DG52.1 GenPept UniProtKB/Swiss-Prot:Q6DG52

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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