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Zfp658 zinc finger protein 658 [ Mus musculus (house mouse) ]

Gene ID: 210104, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp658provided by MGI
Official Full Name
zinc finger protein 658provided by MGI
Primary source
MGI:MGI:2652821
See related
Ensembl:ENSMUSG00000056592 AllianceGenome:MGI:2652821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 3.4), CNS E14 (RPKM 3.0) and 22 other tissues See more
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Genomic context

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See Zfp658 in Genome Data Viewer
Location:
7 B3; 7 28.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43211794..43225566)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43562202..43576142)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Siglec family like 1 Neighboring gene CD33 molecule Neighboring gene STARR-positive B cell enhancer ABC_E9290 Neighboring gene zinc finger protein 719 Neighboring gene STARR-seq mESC enhancer starr_18778 Neighboring gene STARR-seq mESC enhancer starr_18779 Neighboring gene zinc finger protein 819

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC102645

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 658

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008549.2 → NP_001008549.1  zinc finger protein 658

    See identical proteins and their annotated locations for NP_001008549.1

    Status: VALIDATED

    Source sequence(s)
    AC154108
    Consensus CDS
    CCDS39931.1
    UniProtKB/TrEMBL
    Q5PPQ4
    Related
    ENSMUSP00000103606.2, ENSMUST00000107972.8
    Conserved Domains (3) summary
    smart00349
    Location:23 → 80
    KRAB; krueppel associated box
    COG5048
    Location:493 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:638 → 658
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43211794..43225566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540757.4 → XP_006540820.1  zinc finger protein 658 isoform X1

    See identical proteins and their annotated locations for XP_006540820.1

    UniProtKB/TrEMBL
    Q5PPQ4
    Conserved Domains (3) summary
    smart00349
    Location:23 → 80
    KRAB; krueppel associated box
    COG5048
    Location:493 → 887
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:638 → 658
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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