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ERH ERH, mRNA splicing and mitosis factor [ Homo sapiens (human) ]

Gene ID: 2079, updated on 9-Sep-2018

Summary

Official Symbol
ERHprovided by HGNC
Official Full Name
ERH, mRNA splicing and mitosis factorprovided by HGNC
Primary source
HGNC:HGNC:3447
See related
Ensembl:ENSG00000100632 MIM:601191; Vega:OTTHUMG00000171323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DROER
Expression
Ubiquitous expression in colon (RPKM 61.2), kidney (RPKM 56.3) and 25 other tissues See more
Orthologs

Genomic context

See ERH in Genome Data Viewer
Location:
14q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (69380123..69398304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69846840..69865021, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370550 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 16 Neighboring gene uncharacterized LOC105370549 Neighboring gene solute carrier family 39 member 9 Neighboring gene pleckstrin homology and coiled-coil domain containing D1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of enhancer of rudimentary homolog (Drosophila, ERH) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, enhancer of rudimentary homolog (ERH), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ERH is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleoside metabolic process TAS
Traceable Author Statement
more info
PubMed 
pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
methylosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
enhancer of rudimentary homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004450.2NP_004441.1  enhancer of rudimentary homolog

    See identical proteins and their annotated locations for NP_004441.1

    Status: VALIDATED

    Source sequence(s)
    AK130850, U66871
    Consensus CDS
    CCDS9794.1
    UniProtKB/Swiss-Prot
    P84090
    UniProtKB/TrEMBL
    A0A024R6D4
    Related
    ENSP00000451080.1, OTTHUMP00000245828, ENST00000557016.5, OTTHUMT00000412990
    Conserved Domains (1) summary
    pfam01133
    Location:399
    ER; Enhancer of rudimentary

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    69380123..69398304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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