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Erh ERH mRNA splicing and mitosis factor [ Mus musculus (house mouse) ]

Gene ID: 13877, updated on 1-Mar-2024

Summary

Official Symbol
Erhprovided by MGI
Official Full Name
ERH mRNA splicing and mitosis factorprovided by MGI
Primary source
MGI:MGI:108089
See related
Ensembl:ENSMUSG00000021131 AllianceGenome:MGI:108089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mer; Prei1
Summary
Predicted to enable methyl-CpG binding activity. Involved in osteoblast differentiation. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ERH (ERH mRNA splicing and mitosis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 151.7), CNS E14 (RPKM 121.7) and 23 other tissues See more
Orthologs
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Genomic context

See Erh in Genome Data Viewer
Location:
12 C3; 12 36.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80680799..80690616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80634021..80644111, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32643 Neighboring gene predicted gene, 46364 Neighboring gene STARR-seq mESC enhancer starr_32644 Neighboring gene predicted gene, 23817 Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene solute carrier family 39 (zinc transporter), member 9 Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103398, MGC130271, MGC130272

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
part_of methylosome ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
enhancer of rudimentary homolog
Names
preimplantation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347409.2NP_001334338.1  enhancer of rudimentary homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA260264, BU704106, BY085611, DV062839
    Consensus CDS
    CCDS83973.1
    UniProtKB/TrEMBL
    G3UW85
    Related
    ENSMUSP00000129620.2, ENSMUST00000166931.2
    Conserved Domains (1) summary
    pfam01133
    Location:22118
    ER; Enhancer of rudimentary
  2. NM_001409595.1NP_001396524.1  enhancer of rudimentary homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134537
  3. NM_007951.5NP_031977.1  enhancer of rudimentary homolog isoform 1

    See identical proteins and their annotated locations for NP_031977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) r encodes the shortest isoform (1).
    Source sequence(s)
    AA260264, BU704106, DV069684
    Consensus CDS
    CCDS36483.1
    UniProtKB/Swiss-Prot
    P84089
    UniProtKB/TrEMBL
    Q4FZH7
    Related
    ENSMUSP00000021559.8, ENSMUST00000021559.14
    Conserved Domains (1) summary
    pfam01133
    Location:299
    ER; Enhancer of rudimentary

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80680799..80690616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)