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Scarb1 scavenger receptor class B, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20778, updated on 1-Jan-2023

Summary

Official Symbol
Scarb1provided by MGI
Official Full Name
scavenger receptor class B, member 1provided by MGI
Primary source
MGI:MGI:893578
See related
Ensembl:ENSMUSG00000037936 AllianceGenome:MGI:893578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Chohd1; Hlb398; mSR-BI; D5Ertd460e
Summary
Enables amyloid-beta binding activity; apolipoprotein binding activity; and high-density lipoprotein particle binding activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of lipid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; cholesterol catabolic process; and endothelial cell proliferation. Located in caveola; cell surface; and cytoplasm. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; hemolymphoid system gland; and reproductive system. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 762.6), ovary adult (RPKM 288.2) and 7 other tissues See more
Orthologs
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Genomic context

See Scarb1 in Genome Data Viewer
Location:
5 64.11 cM; 5 G1.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125354151..125418158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125277087..125341094, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1533 Neighboring gene predicted gene, 32585 Neighboring gene predicted gene, 32701 Neighboring gene predicted gene, 40323 Neighboring gene predicted gene, 40324

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables apolipoprotein A-I binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables high-density lipoprotein particle receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide immune receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within carotenoid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intestinal lipid absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, recognition ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol storage ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in recognition of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in recognition of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
involved_in recognition of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphatidylcholine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reverse cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vitamin transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
scavenger receptor class B member 1
Names
HDL QTL 1
scavenger receptor class B type I
scavenger receptor class B1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205082.1NP_001192011.1  scavenger receptor class B member 1 isoform 2

    See identical proteins and their annotated locations for NP_001192011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK010622, AK028191, BQ176029, BY018765
    Consensus CDS
    CCDS57383.1
    UniProtKB/Swiss-Prot
    Q61009
    Related
    ENSMUSP00000107021.2, ENSMUST00000111390.8
    Conserved Domains (1) summary
    pfam01130
    Location:26447
    CD36; CD36 family
  2. NM_001205083.1NP_001192012.1  scavenger receptor class B member 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs at the 3' end compared to variant 1. This results in a frame-shift and a longer isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK143368, AK145588, BY018765
    Related
    ENSMUST00000148373.8
    Conserved Domains (1) summary
    pfam01130
    Location:26447
    CD36; CD36 family
  3. NM_016741.2NP_058021.1  scavenger receptor class B member 1 isoform 1

    See identical proteins and their annotated locations for NP_058021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AK028191, BQ176029, BY018765
    Consensus CDS
    CCDS19683.1
    UniProtKB/Swiss-Prot
    Q61009, Q9CWJ7
    UniProtKB/TrEMBL
    A0A8C6GJV2
    Related
    ENSMUSP00000083242.7, ENSMUST00000086075.13
    Conserved Domains (1) summary
    pfam01130
    Location:26447
    CD36; CD36 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    125354151..125418158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164950.1XP_036020843.1  scavenger receptor class B member 1 isoform X2

    Conserved Domains (1) summary
    pfam01130
    Location:11416
    CD36; CD36 family
  2. XM_030254310.1XP_030110170.1  scavenger receptor class B member 1 isoform X4

    Conserved Domains (1) summary
    pfam01130
    Location:1393
    CD36; CD36 family
  3. XM_030254308.1XP_030110168.1  scavenger receptor class B member 1 isoform X3

    Conserved Domains (1) summary
    pfam01130
    Location:1393
    CD36; CD36 family
  4. XM_017320764.2XP_017176253.1  scavenger receptor class B member 1 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:11416
    CD36; CD36 family
  5. XM_030254309.2XP_030110169.1  scavenger receptor class B member 1 isoform X3

    Conserved Domains (1) summary
    pfam01130
    Location:1393
    CD36; CD36 family