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Sptbn1 spectrin beta, non-erythrocytic 1 [ Mus musculus (house mouse) ]

Gene ID: 20742, updated on 11-Sep-2019

Summary

Official Symbol
Sptbn1provided by MGI
Official Full Name
spectrin beta, non-erythrocytic 1provided by MGI
Primary source
MGI:MGI:98388
See related
Ensembl:ENSMUSG00000020315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
elf1; elf3; SPTB2; Spnb2; Spnb-2; AL033301; mKIAA4049; 9930031C03Rik
Expression
Ubiquitous expression in lung adult (RPKM 47.5), frontal lobe adult (RPKM 32.2) and 25 other tissues See more
Orthologs

Genomic context

See Sptbn1 in Genome Data Viewer
Location:
11 A3.3; 11 17.44 cM
Exon count:
41
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30099395..30268384, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (29999395..30119772, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene echinoderm microtubule associated protein like 6 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene PRAME family member 8-like Neighboring gene uncharacterized LOC115487763 Neighboring gene predicted gene 8098 Neighboring gene predicted gene, 40820 Neighboring gene stress-induced phosphoprotein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
actin filament capping IEA
Inferred from Electronic Annotation
more info
 
common-partner SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
membrane assembly ISO
Inferred from Sequence Orthology
more info
 
mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
plasma membrane organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-2 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
M band IDA
Inferred from Direct Assay
more info
PubMed 
axolemma IDA
Inferred from Direct Assay
more info
PubMed 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cuticular plate IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
spectrin IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
spectrin beta chain, non-erythrocytic 1
Names
beta fodrin
beta-II spectrin
beta-spectrin 2, non-erythrocytic
brain spectrin
embryonic liver fodrin
fodrin beta chain
non-erythrocytic
spectrin G
spectrin beta 2
spectrin beta chain, brain 1
spectrin, non-erythroid beta chain 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009260.2NP_033286.2  spectrin beta chain, non-erythrocytic 1 isoform 2

    See identical proteins and their annotated locations for NP_033286.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains different segments for its 5' UTR, 5' coding region, 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has shorter and distinct N- and C- termini when it is compared to isoform 1.
    Source sequence(s)
    AF017112, AK075675, AK157727, AK161119, AK169544, CF539329, CK627078
    Consensus CDS
    CCDS24506.1
    UniProtKB/Swiss-Prot
    Q62261
    UniProtKB/TrEMBL
    Q3TTX2, Q3TZN6
    Related
    ENSMUSP00000099902.3, ENSMUST00000102838.9
    Conserved Domains (3) summary
    cd00014
    Location:161264
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:517730
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:409512
    Spectrin; Spectrin repeat
  2. NM_175836.2NP_787030.2  spectrin beta chain, non-erythrocytic 1 isoform 1

    See identical proteins and their annotated locations for NP_787030.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF017112, AK051630, AK157727, AK169544, AL672225, BC024833, CF539329, CK627078
    Consensus CDS
    CCDS36123.1
    UniProtKB/Swiss-Prot
    Q62261
    UniProtKB/TrEMBL
    Q3TZN6, Q8BQ35, Q8R1C2
    Related
    ENSMUSP00000011877.6, ENSMUST00000011877.12
    Conserved Domains (5) summary
    cd00014
    Location:174277
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:530743
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:21992304
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:21992306
    PH; PH domain
    pfam00435
    Location:422525
    Spectrin; Spectrin repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    30099395..30268384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514599.4XP_006514662.1  spectrin beta chain, non-erythrocytic 1 isoform X1

    See identical proteins and their annotated locations for XP_006514662.1

    UniProtKB/Swiss-Prot
    Q62261
    Related
    ENSMUSP00000006629.7, ENSMUST00000006629.13
    Conserved Domains (5) summary
    cd00014
    Location:174277
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:530743
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:21992304
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:21992306
    PH; PH domain
    pfam00435
    Location:422525
    Spectrin; Spectrin repeat
  2. XM_006514600.4XP_006514663.1  spectrin beta chain, non-erythrocytic 1 isoform X1

    See identical proteins and their annotated locations for XP_006514663.1

    UniProtKB/Swiss-Prot
    Q62261
    Conserved Domains (5) summary
    cd00014
    Location:174277
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:530743
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:21992304
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:21992306
    PH; PH domain
    pfam00435
    Location:422525
    Spectrin; Spectrin repeat
  3. XM_030245736.1XP_030101596.1  spectrin beta chain, non-erythrocytic 1 isoform X1

  4. XM_030245738.1XP_030101598.1  spectrin beta chain, non-erythrocytic 1 isoform X1

  5. XM_030245737.1XP_030101597.1  spectrin beta chain, non-erythrocytic 1 isoform X1

  6. XM_006514601.3XP_006514664.1  spectrin beta chain, non-erythrocytic 1 isoform X2

    Conserved Domains (5) summary
    cd00014
    Location:161264
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:517730
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:21862291
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:21862293
    PH; PH domain
    pfam00435
    Location:409512
    Spectrin; Spectrin repeat
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