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Sp3 trans-acting transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 20687, updated on 18-Apr-2024

Summary

Official Symbol
Sp3provided by MGI
Official Full Name
trans-acting transcription factor 3provided by MGI
Primary source
MGI:MGI:1277166
See related
Ensembl:ENSMUSG00000027109 AllianceGenome:MGI:1277166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D130027J01Rik
Summary
This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta adult (RPKM 16.1), limb E14.5 (RPKM 12.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 C3; 2 43.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72766774..72810790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72936430..72980446, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430710C18 gene Neighboring gene STARR-seq mESC enhancer starr_04823 Neighboring gene predicted gene, 39848 Neighboring gene STARR-seq mESC enhancer starr_04824 Neighboring gene predicted gene, 39849 Neighboring gene STARR-seq mESC enhancer starr_04826 Neighboring gene STARR-seq mESC enhancer starr_04827 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_04828 Neighboring gene STARR-seq mESC enhancer starr_04829 Neighboring gene STARR-positive B cell enhancer mm9_chr2:72835176-72835477 Neighboring gene STARR-positive B cell enhancer mm9_chr2:72841087-72841388 Neighboring gene STARR-seq mESC enhancer starr_04832 Neighboring gene trans-acting transcription factor 3, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:72878181-72878481 Neighboring gene predicted gene, 39850 Neighboring gene STARR-seq mESC enhancer starr_04835 Neighboring gene Obg-like ATPase 1 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105187

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within definitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic placenta development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic process involved in female pregnancy IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within enucleate erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within megakaryocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within trophectodermal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018042.3NP_001018052.1  transcription factor Sp3 isoform 1

    See identical proteins and their annotated locations for NP_001018052.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC079874
    Consensus CDS
    CCDS16122.1
    UniProtKB/Swiss-Prot
    A2AQK9, O70494, Q68FF2, Q8CF64, Q8K378
    UniProtKB/TrEMBL
    Q2M4I5
    Related
    ENSMUSP00000099750.4, ENSMUST00000102689.10
    Conserved Domains (4) summary
    COG5048
    Location:638720
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:625647
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:683705
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:669692
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001098425.1NP_001091895.1  transcription factor Sp3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing 2 exons from the 5' end compared to transcript variant 1, and it initiates translation from an in-frame, downstream non-AUG (AUA) codon, resulting in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC079874, CA328978, CJ167744
    UniProtKB/TrEMBL
    Q2M4I5
    Related
    ENSMUST00000133615.2
    Conserved Domains (4) summary
    COG5048
    Location:571653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:558580
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:616638
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:602625
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    72766774..72810790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011450.1: Suppressed sequence

    Description
    NM_011450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.