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Sox15 SRY (sex determining region Y)-box 15 [ Mus musculus (house mouse) ]

Gene ID: 20670, updated on 5-Mar-2024

Summary

Official Symbol
Sox15provided by MGI
Official Full Name
SRY (sex determining region Y)-box 15provided by MGI
Primary source
MGI:MGI:98363
See related
Ensembl:ENSMUSG00000041287 AllianceGenome:MGI:98363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sox16
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of satellite cell activation involved in skeletal muscle regeneration; and trophoblast giant cell differentiation. Acts upstream of or within several processes, including myoblast development; negative regulation of striated muscle tissue development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and thymus. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.9), placenta adult (RPKM 3.2) and 3 other tissues See more
Orthologs
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Genomic context

Location:
11 B3; 11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69545863..69547553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69655037..69656727)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene FMR1 autosomal homolog 2 Neighboring gene microRNA 467f Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene STARR-positive B cell enhancer ABC_E3965 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69476301-69476484 Neighboring gene microRNA 1934 Neighboring gene CD68 antigen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myoblast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of satellite cell activation involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein SOX-15
Names
SRY (sex determining region Y)-box 16
SRY-box containing gene 15
SRY-box containing gene 16
protein SOX-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009235.2NP_033261.1  protein SOX-15

    See identical proteins and their annotated locations for NP_033261.1

    Status: VALIDATED

    Source sequence(s)
    AK131957, BU758023
    Consensus CDS
    CCDS24902.1
    UniProtKB/Swiss-Prot
    O70204, P43267, P70418, Q62246, Q91V00, Q91V43, Q920T1, Q9JLG2
    UniProtKB/TrEMBL
    Q5F2B2
    Related
    ENSMUSP00000048524.6, ENSMUST00000047373.6
    Conserved Domains (1) summary
    cd01388
    Location:46117
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69545863..69547553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)