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SOX15 SRY-box transcription factor 15 [ Homo sapiens (human) ]

Gene ID: 6665, updated on 21-Dec-2019

Summary

Official Symbol
SOX15provided by HGNC
Official Full Name
SRY-box transcription factor 15provided by HGNC
Primary source
HGNC:HGNC:11196
See related
Ensembl:ENSG00000129194 MIM:601297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOX20; SOX26; SOX27
Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 12.3), esophagus (RPKM 6.9) and 8 other tissues See more
Orthologs

Genomic context

See SOX15 in Genome Data Viewer
Location:
17p13.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7588178..7590094, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7491496..7494037, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene uncharacterized LOC100996842 Neighboring gene small nucleolar RNA, H/ACA box 67 Neighboring gene CD68 molecule Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene FMR1 autosomal homolog 2 Neighboring gene tRNA-undetermined (NNN) 6-1 Neighboring gene sex hormone binding globulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
male gonad development TAS
Traceable Author Statement
more info
PubMed 
myoblast development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of G0 to G1 transition ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of myoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of satellite cell activation involved in skeletal muscle regeneration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein SOX-15
Names
SRY (sex determining region Y)-box 15
SRY (sex determining region Y)-box 20
SRY-box 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006942.2NP_008873.1  protein SOX-15

    See identical proteins and their annotated locations for NP_008873.1

    Status: REVIEWED

    Source sequence(s)
    AB006867, AC016876
    Consensus CDS
    CCDS32549.1
    UniProtKB/Swiss-Prot
    O60248
    Related
    ENSP00000355354.2, ENST00000250055.3
    Conserved Domains (1) summary
    cd01388
    Location:48119
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7588178..7590094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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