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Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20662, updated on 8-Feb-2024

Summary

Official Symbol
Sos1provided by MGI
Official Full Name
SOS Ras/Rac guanine nucleotide exchange factor 1provided by MGI
Primary source
MGI:MGI:98354
See related
Ensembl:ENSMUSG00000024241 AllianceGenome:MGI:98354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630010N06; 4430401P03Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including neuronal cell body; plasma membrane; and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 5.3), cerebellum adult (RPKM 5.1) and 28 other tissues See more
Orthologs
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Genomic context

See Sos1 in Genome Data Viewer
Location:
17 E3; 17 50.67 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80701181..80787882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80393752..80480453, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene MORN repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene STARR-positive B cell enhancer ABC_E8924 Neighboring gene STARR-positive B cell enhancer ABC_E2500 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8925 Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene STARR-seq mESC enhancer starr_43318 Neighboring gene STARR-positive B cell enhancer ABC_E5633 Neighboring gene STARR-positive B cell enhancer ABC_E10973 Neighboring gene STARR-positive B cell enhancer ABC_E9172 Neighboring gene STARR-positive B cell enhancer ABC_E4229 Neighboring gene STARR-positive B cell enhancer ABC_E616 Neighboring gene cyclin dependent kinase like 4 Neighboring gene STARR-seq mESC enhancer starr_43322 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_43326 Neighboring gene STARR-seq mESC enhancer starr_43329 Neighboring gene predicted gene 9959

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in B cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of pro-B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vitellogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of GTPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
son of sevenless homolog 1
Names
guanine nucleotide releasing factor
ras guanine exchange factor
son-of-sevenless 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009231.2NP_033257.2  son of sevenless homolog 1

    See identical proteins and their annotated locations for NP_033257.2

    Status: VALIDATED

    Source sequence(s)
    AC161447, AK140310, CB521016
    Consensus CDS
    CCDS37704.1
    UniProtKB/Swiss-Prot
    Q62244, Q62245
    UniProtKB/TrEMBL
    Q2M4G6
    Related
    ENSMUSP00000067786.6, ENSMUST00000068714.7
    Conserved Domains (6) summary
    smart00229
    Location:597741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:7761015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445546
    PH; PH domain
    cl23907
    Location:97177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80701181..80787882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160425.1XP_036016318.1  son of sevenless homolog 1 isoform X1

    Conserved Domains (4) summary
    PTZ00449
    Location:606894
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:186330
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:365604
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:28134
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain