Format

Send to:

Choose Destination

Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20662, updated on 19-Feb-2019

Summary

Official Symbol
Sos1provided by MGI
Official Full Name
SOS Ras/Rac guanine nucleotide exchange factor 1provided by MGI
Primary source
MGI:MGI:98354
See related
Ensembl:ENSMUSG00000024241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI449023; 9630010N06; 4430401P03Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 5.3), cerebellum adult (RPKM 5.1) and 28 other tissues See more
Orthologs

Genomic context

See Sos1 in Genome Data Viewer
Location:
17 E3; 17 50.67 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (80393752..80480453, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (80793092..80879793, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 Neighboring gene MORN repeat containing 2 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 33 Neighboring gene predicted gene 10190 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene cyclin-dependent kinase-like 4 Neighboring gene RIKEN cDNA F420015M19 gene Neighboring gene predicted gene, 33373

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Ras guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
Ras guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of pro-B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitellogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
son of sevenless homolog 1
Names
guanine nucleotide releasing factor
ras guanine exchange factor
son-of-sevenless 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009231.2NP_033257.2  son of sevenless homolog 1

    See identical proteins and their annotated locations for NP_033257.2

    Status: VALIDATED

    Source sequence(s)
    AC161447, AK140310, CB521016
    Consensus CDS
    CCDS37704.1
    UniProtKB/Swiss-Prot
    Q62245
    UniProtKB/TrEMBL
    Q3USK4
    Related
    ENSMUSP00000067786.5, ENSMUST00000068714.6
    Conserved Domains (6) summary
    smart00229
    Location:597741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:7761015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445546
    PH; PH domain
    cl23907
    Location:97177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    80393752..80480453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center