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Sin3a transcriptional regulator, SIN3A (yeast) [ Mus musculus (house mouse) ]

Gene ID: 20466, updated on 22-Jan-2023

Summary

Official Symbol
Sin3aprovided by MGI
Official Full Name
transcriptional regulator, SIN3A (yeast)provided by MGI
Primary source
MGI:MGI:107157
See related
Ensembl:ENSMUSG00000042557 AllianceGenome:MGI:107157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sin3; mSin3A; mKIAA4126
Summary
Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in several processes, including cerebral cortex neuron differentiation; negative regulation of circadian rhythm; and regulation of axon extension. Acts upstream of or within several processes, including cellular response to glucose stimulus; positive regulation of G2/M transition of mitotic cell cycle; and response to methylglyoxal. Located in kinetochore and nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.1), thymus adult (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sin3a in Genome Data Viewer
Location:
9 B; 9 30.89 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56979271..57035652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57071991..57128368)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene snurportin 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene nei endonuclease VIII-like 1 (E. coli)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4126

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of histone H3-K27 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hormone levels ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to methylglyoxal IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
paired amphipathic helix protein Sin3a
Names
histone deacetylase complex subunit Sin3a
transcriptional corepressor Sin3a
transcriptional regulator, SIN3 yeast homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110350.1NP_001103820.1  paired amphipathic helix protein Sin3a isoform 2

    See identical proteins and their annotated locations for NP_001103820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is longer compared to isoform 1.
    Source sequence(s)
    AC132406, AK220292, BC078454
    Consensus CDS
    CCDS52805.1
    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Related
    ENSMUSP00000130221.2, ENSMUST00000168177.8
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  2. NM_001110351.1NP_001103821.1  paired amphipathic helix protein Sin3a isoform 1

    See identical proteins and their annotated locations for NP_001103821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AK032209, BC078454, BY020498
    Consensus CDS
    CCDS23216.1
    UniProtKB/Swiss-Prot
    Q60520, Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Related
    ENSMUSP00000130641.2, ENSMUST00000167715.8
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  3. NM_001357754.1NP_001344683.1  paired amphipathic helix protein Sin3a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC132406
    Consensus CDS
    CCDS23216.1
    UniProtKB/Swiss-Prot
    Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  4. NM_011378.2NP_035508.2  paired amphipathic helix protein Sin3a isoform 1

    See identical proteins and their annotated locations for NP_035508.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript but encodes the shorter isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC132406, AK032209, AK220292, BC078454, L38620
    Consensus CDS
    CCDS23216.1
    UniProtKB/Swiss-Prot
    Q60520, Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Related
    ENSMUSP00000126601.2, ENSMUST00000168678.8
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56979271..57035652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242683.3XP_011240985.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_011240985.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Related
    ENSMUSP00000128956.2, ENSMUST00000168502.8
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  2. XM_006510891.3XP_006510954.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006510954.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  3. XM_036154748.1XP_036010641.1  paired amphipathic helix protein Sin3a isoform X2

    UniProtKB/Swiss-Prot
    Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Related
    ENSMUSP00000045044.6, ENSMUST00000049169.6
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  4. XM_006510893.4XP_006510956.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006510956.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  5. XM_030244150.1XP_030100010.1  paired amphipathic helix protein Sin3a isoform X2

    UniProtKB/Swiss-Prot
    Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  6. XM_011242685.4XP_011240987.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_011240987.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  7. XM_036154746.1XP_036010639.1  paired amphipathic helix protein Sin3a isoform X2

    UniProtKB/Swiss-Prot
    Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  8. XM_011242684.4XP_011240986.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_011240986.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  9. XM_006510892.5XP_006510955.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006510955.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  10. XM_011242686.4XP_011240988.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_011240988.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  11. XM_036154747.1XP_036010640.1  paired amphipathic helix protein Sin3a isoform X2

    UniProtKB/Swiss-Prot
    Q7TSZ2
    UniProtKB/TrEMBL
    A0A6P5QD67, A0A8C6GSM0
    Conserved Domains (1) summary
    COG5602
    Location:81214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
  12. XM_006510890.5XP_006510953.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006510953.1

    UniProtKB/Swiss-Prot
    Q60520
    UniProtKB/TrEMBL
    A0A6P7R9Z9
    Conserved Domains (1) summary
    COG5602
    Location:81217
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]