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SIN3A SIN3 transcription regulator family member A [ Homo sapiens (human) ]

Gene ID: 25942, updated on 17-Jun-2019

Summary

Official Symbol
SIN3Aprovided by HGNC
Official Full Name
SIN3 transcription regulator family member Aprovided by HGNC
Primary source
HGNC:HGNC:19353
See related
Ensembl:ENSG00000169375 MIM:607776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WITKOS
Summary
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues See more
Orthologs

Genomic context

See SIN3A in Genome Data Viewer
Location:
15q24.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75369379..75455819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75661720..75748181, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 58 Neighboring gene nei like DNA glycosylase 1 Neighboring gene microRNA 631 Neighboring gene mannosidase alpha class 2C member 1 Neighboring gene ribosomal protein L13 pseudogene 4 Neighboring gene uncharacterized LOC105370902 Neighboring gene protein tyrosine phosphatase non-receptor type 9 Neighboring gene small nuclear ribonucleoprotein F-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Witteveen-kolk syndrome
MedGen: C4310804 OMIM: 613406 GeneReviews: 15q24 Microdeletion
not available

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
integrase gag-pol HIV-1 IN and INI1/hSNF5 bind SAP18 and selectively recruit components of Sin3a-HDAC1 complex into HIV-1 virions. HIV-1 virion-associated HDAC1 is required for efficient early post-entry events PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90319, KIAA0700, DKFZp434K2235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cellular response to dopamine IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of histone H3-K27 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hormone levels IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to methylglyoxal IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
Sin3 complex NAS
Non-traceable Author Statement
more info
PubMed 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
paired amphipathic helix protein Sin3a
Names
SIN3 homolog A, transcription regulator
histone deacetylase complex subunit Sin3a
transcriptional co-repressor Sin3A
transcriptional corepressor Sin3a
transcriptional regulator, SIN3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052855.1 RefSeqGene

    Range
    5001..91405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145357.2NP_001138829.1  paired amphipathic helix protein Sin3a

    See identical proteins and their annotated locations for NP_001138829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AC105137, AF418569, AL832463, BM676304
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Related
    ENSP00000353622.4, ENST00000360439.8
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
  2. NM_001145358.2NP_001138830.1  paired amphipathic helix protein Sin3a

    See identical proteins and their annotated locations for NP_001138830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AF418569, AK096477, BM676304
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Related
    ENSP00000378402.3, ENST00000394947.7
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
  3. NM_015477.3NP_056292.1  paired amphipathic helix protein Sin3a

    See identical proteins and their annotated locations for NP_056292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AC105137, AF418569, BC041047, BM676304
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Related
    ENSP00000378403.4, ENST00000394949.8
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75369379..75455819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720465.3XP_006720528.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006720528.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
  2. XM_006720467.3XP_006720530.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006720530.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
  3. XM_006720466.3XP_006720529.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006720529.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
  4. XM_024449896.1XP_024305664.1  paired amphipathic helix protein Sin3a isoform X1

    Conserved Domains (1) summary
    cl07053
    Location:51213
    Sin3_corepress; Sin3 family co-repressor
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