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St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20441, updated on 9-Mar-2023

Summary

Official Symbol
St3gal3provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:1316659
See related
Ensembl:ENSMUSG00000028538 AllianceGenome:MGI:1316659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST3N; Siat3; Siat6; ST3GalIII
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 43.9), adrenal adult (RPKM 31.6) and 25 other tissues See more
Orthologs
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Genomic context

See St3gal3 in Genome Data Viewer
Location:
4; 4 D1- D2.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117789349..117992169, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117932152..118134972, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene importin 13 Neighboring gene artemin Neighboring gene RIKEN cDNA 9530034E10 gene Neighboring gene predicted gene, 54253 Neighboring gene lysine (K)-specific demethylase 4A Neighboring gene predicted gene, 23382 Neighboring gene predicted gene, 54252

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Names
N-acetyllactosaminide alpha-2,3-sialyltransferase
alpha 2,3-ST 3
beta-galactoside alpha-2,3-sialyltransferase 3
gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
sialyltransferase 3
sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
NP_001155246.1
NP_001272449.1
NP_001272450.1
NP_033202.3
XP_006502953.1
XP_006502954.1
XP_006502955.1
XP_006502956.1
XP_006502957.1
XP_006502958.1
XP_006502959.1
XP_006502960.1
XP_006502961.1
XP_006502962.1
XP_030109232.1
XP_030109233.1
XP_030109234.1
XP_030109235.1
XP_036019823.1
XP_036019824.1
XP_036019825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161774.2NP_001155246.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_001155246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK013016, BB868500, BF472945, CX240214
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    A0A8C6H9I2, Q9CZ48
    Related
    ENSMUSP00000102018.2, ENSMUST00000106410.8
    Conserved Domains (1) summary
    pfam00777
    Location:106370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001285520.1NP_001272449.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_001272449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK005053, AK136442, BB868500, BF472945
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    A0A8C6H9I2, Q3UWD5, Q9DBB6
    Conserved Domains (1) summary
    pfam00777
    Location:106370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001285521.1NP_001272450.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b

    See identical proteins and their annotated locations for NP_001272450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK013016, BB868500, BF472945
    Consensus CDS
    CCDS71458.1
    UniProtKB/TrEMBL
    A0A8C6MWB9, Q9CZ48
    Related
    ENSMUSP00000095525.2, ENSMUST00000097912.8
    Conserved Domains (1) summary
    pfam00777
    Location:90354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_009176.5NP_033202.3  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_033202.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK005053, AK136442, AL611952, BB868500, BF472945
    Consensus CDS
    CCDS18544.1
    UniProtKB/Swiss-Prot
    P97325, Q922X5
    UniProtKB/TrEMBL
    A0A8C6H9I2, Q3UWD5, Q9DBB6
    Related
    ENSMUSP00000030263.3, ENSMUST00000030263.9
    Conserved Domains (1) summary
    pfam00777
    Location:106370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117789349..117992169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502898.4XP_006502961.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

    See identical proteins and their annotated locations for XP_006502961.1

    UniProtKB/TrEMBL
    A0A8C6MWB9, Q9CZ48
    Conserved Domains (1) summary
    pfam00777
    Location:90354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_006502895.1XP_006502958.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006502958.1

    Conserved Domains (1) summary
    pfam00777
    Location:106398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_036163930.1XP_036019823.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:128392
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_036163931.1XP_036019824.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

    UniProtKB/TrEMBL
    A0A8C6MWB9, Q9CZ48
    Conserved Domains (1) summary
    pfam00777
    Location:90354
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_030253375.1XP_030109235.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:112376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_030253374.2XP_030109234.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:90382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_006502892.3XP_006502955.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502955.1

    Conserved Domains (1) summary
    pfam00777
    Location:128420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_006502894.2XP_006502957.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006502957.1

    Conserved Domains (1) summary
    pfam00777
    Location:106398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_030253373.1XP_030109233.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:90382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. XM_030253372.1XP_030109232.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:106398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. XM_006502891.3XP_006502954.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502954.1

    Conserved Domains (1) summary
    pfam00777
    Location:128420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. XM_006502897.3XP_006502960.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:90382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. XM_006502893.3XP_006502956.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:112404
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  14. XM_006502896.3XP_006502959.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:128392
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  15. XM_006502890.3XP_006502953.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006502953.1

    Conserved Domains (1) summary
    pfam00777
    Location:128420
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  16. XM_036163932.1XP_036019825.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X9

    Conserved Domains (1) summary
    pfam00777
    Location:128276
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  17. XM_006502899.3XP_006502962.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X8

    Conserved Domains (1) summary
    pfam00777
    Location:128271
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_004941855.1 RNA Sequence

  2. XR_376302.4 RNA Sequence

  3. XR_376301.3 RNA Sequence