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ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 6487, updated on 4-Nov-2022

Summary

Official Symbol
ST3GAL3provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:10866
See related
Ensembl:ENSG00000126091 MIM:606494; AllianceGenome:HGNC:10866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST3N; DEE15; MRT12; SIAT6; EIEE15; ST3GALII; ST3GalIII; ST3Gal III
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 4.7), fat (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See ST3GAL3 in Genome Data Viewer
Location:
1p34.1
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43707536..43931159)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43578028..43802236)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44173207..44396831)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904165 Neighboring gene lysine demethylase 4A Neighboring gene KDM4A antisense RNA 1 Neighboring gene ST3GAL3 antisense RNA 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC124904166 Neighboring gene microRNA 6079 Neighboring gene SHMT1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 749 Neighboring gene Sharpr-MPRA regulatory region 11119 Neighboring gene long intergenic non-protein coding RNA 2918 Neighboring gene artemin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 15
MedGen: C3554316 OMIM: 615006 GeneReviews: Not available
Compare labs
Intellectual disability, autosomal recessive 12
MedGen: C1970200 OMIM: 611090 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of aging.
EBI GWAS Catalog
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (ST3GAL3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
 
involved_in ganglioside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
 
involved_in keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
 
involved_in viral protein processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Names
Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase
alpha 2,3-ST 3
alpha 2,3-sialyltransferase III
alpha-2,3-sialyltransferase II
sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
sialyltransferase 6 (N-acetyllactosaminide alpha 2,3-sialyltransferase)
NP_001257388.1
NP_001257389.1
NP_001257390.1
NP_001257391.1
NP_001257392.1
NP_001257393.1
NP_001257394.1
NP_001257395.1
NP_001337548.1
NP_001337549.1
NP_001337550.1
NP_001350502.1
NP_006270.1
NP_777623.2
NP_777624.1
NP_777625.1
NP_777626.1
NP_777627.1
NP_777628.2
NP_777629.1
NP_777630.1
NP_777631.2
XP_006710890.1
XP_011540275.1
XP_011540276.1
XP_011540278.1
XP_011540282.1
XP_011540283.1
XP_011540286.1
XP_011540287.1
XP_011540288.1
XP_011540290.1
XP_016857602.1
XP_016857605.1
XP_047284140.1
XP_047284141.1
XP_047284155.1
XP_047284156.1
XP_047284157.1
XP_047284177.1
XP_047284188.1
XP_047284192.1
XP_047284217.1
XP_047284221.1
XP_047284226.1
XP_047284229.1
XP_047284230.1
XP_047284232.1
XP_047284236.1
XP_047284238.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028196.2 RefSeqGene

    Range
    5002..228625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270459.2NP_001257388.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform k

    See identical proteins and their annotated locations for NP_001257388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate in-frame exon, uses an alternate in-frame splice site in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoforom (k, also called B1-90) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425854, AL357079, AL451062
    Consensus CDS
    CCDS57988.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000361444.1, ENST00000372369.5
    Conserved Domains (1) summary
    pfam00777
    Location:126341
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001270460.2NP_001257389.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform l

    See identical proteins and their annotated locations for NP_001257389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (l, also called B4+173) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425855, AL357079, AL451062
    Consensus CDS
    CCDS57989.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000361449.2, ENST00000372374.7
    Conserved Domains (1) summary
    pfam00777
    Location:95340
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001270461.3NP_001257390.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform m

    See identical proteins and their annotated locations for NP_001257390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) uses an alternate in-frame splice site in the 5' coding region and lacks four alternate in-frame exons compared to variant 1. The resulting isoform (m, also called C4) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AL357079, AY167993, DR003980, HY013772
    Consensus CDS
    CCDS57990.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000494146.1, ENST00000642934.1
    Conserved Domains (1) summary
    pfam00777
    Location:91247
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001270462.3NP_001257391.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform n

    See identical proteins and their annotated locations for NP_001257391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) uses an alternate in-frame splice site in the 5' coding region, lacks five alternate in-frame exons compared to variant 1. The resulting isoform (n, also called C11) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AL357079, AY167997, DR003980, HY013772
    Consensus CDS
    CCDS85964.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000432682.2, ENST00000531993.6
    Conserved Domains (1) summary
    pfam00777
    Location:60216
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001270463.3NP_001257392.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform o

    See identical proteins and their annotated locations for NP_001257392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) lacks five alternate in-frame exons compared to variant 1. The resulting isoform (o, also called D5) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AL357079, AY167994, DR003980, HY013772
    Consensus CDS
    CCDS57993.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000361442.1, ENST00000372367.5
    Conserved Domains (1) summary
    pfam00777
    Location:106183
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001270464.3NP_001257393.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform p

    See identical proteins and their annotated locations for NP_001257393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) uses an alternate in-frame splice site in the 5' coding region and lacks five alternate in-frame exon compared to variant 1. The resulting isoform (p, also called C5) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AL357079, AY167995, DR003980, HY013772
    Consensus CDS
    CCDS57991.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000434876.1, ENST00000528371.5
    Conserved Domains (1) summary
    pfam00777
    Location:91168
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001270465.3NP_001257394.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform q

    See identical proteins and their annotated locations for NP_001257394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks two alternate in-frame exons, uses an alternate splice site which results in a frameshift and lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (q, also called D2+26) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA478788, AF425863, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS57994.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000335633.7, ENST00000335430.10
    Conserved Domains (1) summary
    pfam00777
    Location:125185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001270466.3NP_001257395.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform r

    See identical proteins and their annotated locations for NP_001257395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) uses an alternate in-frame splice site in the 5' coding region and lacks eight alternate in-frame exons compared to variant 1. The resulting isoform (r, also called C12) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AL357079, AL592548, AY167998, DR003980, HY013772
    Consensus CDS
    CCDS57992.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000333494.3, ENST00000330208.6
    Conserved Domains (2) summary
    PRK05428
    Location:3155
    PRK05428; HPr kinase/phosphorylase; Provisional
    PRK05673
    Location:5383
    dnaE; DNA polymerase III subunit alpha; Validated
  9. NM_001350619.2NP_001337548.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform s

    Status: REVIEWED

    Source sequence(s)
    AA478788, AF425855, AL357079, BC050380, BI832120, DR003980, HY013772
    Consensus CDS
    CCDS85965.1
    UniProtKB/TrEMBL
    A0A2R8YDJ6
    Related
    ENSP00000493823.1, ENST00000642331.1
    Conserved Domains (1) summary
    pfam00777
    Location:141353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. NM_001350620.2NP_001337549.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform t

    Status: REVIEWED

    Source sequence(s)
    AA478788, AF425855, AL357079, BC050380, BI832120, DN999880, HY013772
    Consensus CDS
    CCDS85962.1
    UniProtKB/TrEMBL
    A0A2R8Y6H4
    Related
    ENSP00000495333.1, ENST00000643252.1
    Conserved Domains (1) summary
    pfam00777
    Location:126338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. NM_001350621.2NP_001337550.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform u

    Status: REVIEWED

    Source sequence(s)
    AA478788, AF425855, AL357079, AL521256, BC050380, BI832120, DN999880, HY013772
    Conserved Domains (1) summary
    pfam00777
    Location:33245
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. NM_001363573.2NP_001350502.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform v

    Status: REVIEWED

    Source sequence(s)
    AL357079, AL451062, AL592548
    Consensus CDS
    CCDS85961.1
    UniProtKB/TrEMBL
    A0A2R8Y6L4
    Related
    ENSP00000495624.1, ENST00000647237.1
    Conserved Domains (1) summary
    pfam00777
    Location:180318
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. NM_001410781.1NP_001397710.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform w

    Status: REVIEWED

    Source sequence(s)
    AL357079, AL451062, AL592548
    Consensus CDS
    CCDS90936.1
    UniProtKB/TrEMBL
    A0A2R8Y732
  14. NM_006279.5NP_006270.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform j

    See identical proteins and their annotated locations for NP_006270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (j, also called B1) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, BC050380, HY013772
    Consensus CDS
    CCDS492.1
    UniProtKB/Swiss-Prot
    Q11203, Q8IX58
    Related
    ENSP00000317192.6, ENST00000347631.8
    Conserved Domains (1) summary
    pfam00777
    Location:107371
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  15. NM_174963.5NP_777623.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_777623.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also called A8).
    Source sequence(s)
    AF425853, AK301829, AL357079, BC050380, HY013772
    Consensus CDS
    CCDS493.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000262915.3, ENST00000262915.8
    Conserved Domains (1) summary
    pfam00777
    Location:195440
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  16. NM_174964.4NP_777624.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b

    See identical proteins and their annotated locations for NP_777624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b, also called A1) that is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425851, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS494.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000355341.5, ENST00000361392.9
    Conserved Domains (1) summary
    pfam00777
    Location:122386
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  17. NM_174965.4NP_777625.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform c

    See identical proteins and their annotated locations for NP_777625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (c, also called A7) has a distinct C-terminus and is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425852, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS499.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000439634.1, ENST00000545417.5
  18. NM_174966.4NP_777626.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform d

    See identical proteins and their annotated locations for NP_777626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (d, also called B4) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425856, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS495.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000330463.3, ENST00000353126.8
    Conserved Domains (1) summary
    pfam00777
    Location:107263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  19. NM_174967.4NP_777627.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform e

    See identical proteins and their annotated locations for NP_777627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (e, also called B7) has a distinct C-terminus and is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425857, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS500.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000361437.2, ENST00000372362.6
  20. NM_174968.5NP_777628.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform f

    See identical proteins and their annotated locations for NP_777628.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) utilizes an alternate in-frame splice site compared to variant 1, resulting in an isoform (f, also called B8) that is shorter compared to isoform a.
    Source sequence(s)
    AF425858, AK301829, AL357079, BC050380, HY013772
    Consensus CDS
    CCDS496.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000316999.6, ENST00000351035.8
    Conserved Domains (1) summary
    pfam00777
    Location:180425
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  21. NM_174969.4NP_777629.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform g

    See identical proteins and their annotated locations for NP_777629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (g, also called C1) is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425859, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS497.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000354748.4, ENST00000361400.9
    Conserved Domains (1) summary
    pfam00777
    Location:91355
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  22. NM_174970.4NP_777630.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform h

    See identical proteins and their annotated locations for NP_777630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (h, also called C7) has a distinct C-terminus and is shorter compared to isoform a.
    Source sequence(s)
    AA478788, AF425860, AL357079, DR003980, HY013772
    Consensus CDS
    CCDS53310.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000435603.1, ENST00000531451.5
  23. NM_174971.5NP_777631.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform i

    See identical proteins and their annotated locations for NP_777631.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame segment compared to variant 1, resulting in an isoform (i, also called C8) that is shorter compared to isoform a.
    Source sequence(s)
    AF425861, AK301829, AL357079, BC050380, HY013772
    Consensus CDS
    CCDS498.1
    UniProtKB/Swiss-Prot
    Q11203
    Related
    ENSP00000361447.2, ENST00000372372.7
    Conserved Domains (1) summary
    pfam00777
    Location:164409
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_073016.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AF425864, AL357079, DR003980, HY013772
    Related
    ENST00000642949.1
  2. NR_073017.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) lacks three alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AF425868, AL357079, DR003980, HY013772
    Related
    ENST00000646027.1
  3. NR_073018.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AF425865, AL357079, AL592548, DR003980, HY013772
    Related
    ENST00000643597.1
  4. NR_073019.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) lacks alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AF425869, AL357079, DR003980, HY013772
  5. NR_073020.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AL357079, AL592548, AY167996, DR003980, HY013772
  6. NR_073021.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AF425867, AL357079, DR003980, HY013772
  7. NR_073023.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) lacks three alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA478788, AL357079, AL451062, AY167992, DR003980, HY013772
    Related
    ENST00000642194.1
  8. NR_146867.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA478788, AF425855, AL357079, BC050380, BI822816, DN999880, HY013772
    Related
    ENST00000645142.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    43707536..43931159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428200.1XP_047284156.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y6H4
  2. XM_047428221.1XP_047284177.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X9

    UniProtKB/Swiss-Prot
    Q8IX58
  3. XM_047428184.1XP_047284140.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

  4. XM_011541981.3XP_011540283.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X11

    Conserved Domains (1) summary
    pfam00777
    Location:176335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_047428270.1XP_047284226.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X15

    Related
    ENSP00000496289.1, ENST00000644922.1
  6. XM_011541974.3XP_011540276.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:161404
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_011541976.3XP_011540278.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:145388
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_006710827.5XP_006710890.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X6

    Related
    ENSP00000495683.1, ENST00000646686.1
    Conserved Domains (1) summary
    pfam00777
    Location:91334
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_011541973.3XP_011540275.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:176419
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. XM_011541986.4XP_011540288.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X13

    See identical proteins and their annotated locations for XP_011540288.1

    Conserved Domains (1) summary
    pfam00777
    Location:176317
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. XM_011541985.3XP_011540287.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X13

    See identical proteins and their annotated locations for XP_011540287.1

    Conserved Domains (1) summary
    pfam00777
    Location:176317
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. XM_011541984.3XP_011540286.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X13

    See identical proteins and their annotated locations for XP_011540286.1

    Conserved Domains (1) summary
    pfam00777
    Location:176317
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. XM_047428274.1XP_047284230.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X16

  14. XM_047428276.1XP_047284232.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X17

  15. XM_047428280.1XP_047284236.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X18

  16. XM_047428185.1XP_047284141.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

  17. XM_047428273.1XP_047284229.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X15

  18. XM_047428232.1XP_047284188.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X10

  19. XM_047428199.1XP_047284155.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y6H4
  20. XM_017002113.2XP_016857602.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X9

    UniProtKB/Swiss-Prot
    Q11203, Q8IX58
    Related
    ENSP00000494201.1, ENST00000644195.1
    Conserved Domains (1) summary
    pfam00777
    Location:107371
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  21. XM_047428201.1XP_047284157.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

  22. XM_047428236.1XP_047284192.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X12

  23. XM_017002116.2XP_016857605.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X12

    Conserved Domains (1) summary
    pfam00777
    Location:13256
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  24. XM_047428265.1XP_047284221.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X7

  25. XM_047428282.1XP_047284238.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X12

  26. XM_011541980.4XP_011540282.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X8

    Conserved Domains (1) summary
    pfam00777
    Location:52295
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  27. XM_047428261.1XP_047284217.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X14

  28. XM_011541988.3XP_011540290.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X14

    See identical proteins and their annotated locations for XP_011540290.1

    Conserved Domains (1) summary
    pfam00777
    Location:1243
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_946744.3 RNA Sequence

  2. XR_946743.3 RNA Sequence

  3. XR_007063036.1 RNA Sequence

  4. XR_946742.3 RNA Sequence

  5. XR_007063037.1 RNA Sequence

  6. XR_007063040.1 RNA Sequence

  7. XR_007063042.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    43578028..43802236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_174972.1: Suppressed sequence

    Description
    NM_174972.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.