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Conserved domains on  [gi|1720407994|ref|XP_030109232|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-389 1.85e-158

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467709  Cd Length: 207  Bit Score: 444.37  E-value: 1.85e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKERVpfpskakcrqcqvgseqerrqksgpdaqSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLP 315
Cdd:cd23981    82 KWLKYIVYKEKV----------------------------SASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLP 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 316 FNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23981   134 FNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-389 1.85e-158

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 444.37  E-value: 1.85e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKERVpfpskakcrqcqvgseqerrqksgpdaqSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLP 315
Cdd:cd23981    82 KWLKYIVYKEKV----------------------------SASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLP 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 316 FNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23981   134 FNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-394 4.58e-85

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 259.46  E-value: 4.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 115 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 194
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 195 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVPFPSKAKcrqcqvgseqerr 267
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVL------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 268 qksgpdaqsasdGFWKSVatRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVA 347
Cdd:pfam00777 149 ------------YTLKEV--KIPVDPDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLY 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1720407994 348 GFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARV 394
Cdd:pfam00777 210 GFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-389 1.85e-158

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 444.37  E-value: 1.85e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKERVpfpskakcrqcqvgseqerrqksgpdaqSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLP 315
Cdd:cd23981    82 KWLKYIVYKEKV----------------------------SASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLP 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 316 FNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23981   134 FNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 156-389 1.34e-123

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 355.83  E-value: 1.34e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23967     2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKERVPFpskakcrqcqvgseqerrqksgpdaqsaSDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLP 315
Cdd:cd23967    82 LWLQAVIKGKKPNG----------------------------KGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLP 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 316 FNNglMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23967   134 MNG--KQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 155-389 1.07e-86

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 261.98  E-value: 1.07e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 234
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 235 FKWLKYIVYKERVPFPSKAkcrqcqvgseqerrqksgpdaqsasdGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL 314
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRL--------------------------FFWKEVADSIPLKPSQFRILNPLIIKETALDILQY 134

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720407994 315 --PFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23983   135 pePQSRLWGWDKNVPTLGVTAVVLATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-394 4.58e-85

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 259.46  E-value: 4.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 115 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 194
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 195 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVPFPSKAKcrqcqvgseqerr 267
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVL------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 268 qksgpdaqsasdGFWKSVatRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVA 347
Cdd:pfam00777 149 ------------YTLKEV--KIPVDPDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLY 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1720407994 348 GFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARV 394
Cdd:pfam00777 210 GFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 156-389 2.50e-71

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 222.70  E-value: 2.50e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKERVpfpskakcrqcqvgseqerrqksgpdaqsASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLP 315
Cdd:cd23984    82 RWLLDLLMGKKV-----------------------------SAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFP 132

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 316 FNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 389
Cdd:cd23984   133 KRFPKEKKPKHPTTGIIAITLALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 156-389 8.76e-70

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 218.38  E-value: 8.76e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQD 234
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 235 FKWLKYIVYKERVPfpskakcrqcqvgseqerrqksgpdaqsaSDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL 314
Cdd:cd23982    82 FYWLYEILSNEKRV-----------------------------RKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQV 132

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407994 315 PfnnGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGY-DMNTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKL 389
Cdd:cd23982   133 P---GQRKKKQKPTTGLLAITLALHLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 159-389 4.76e-48

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 162.15  E-value: 4.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 159 CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 229
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 230 FKWQDFKWLKYivykervpfpskaKCRqcqvgseqerrqksgpdaqsasdgfwksvatRVPKEPPEIRILNPYFIQEAAF 309
Cdd:cd19952    81 AAAADFKRLKR-------------RKK-------------------------------RHDNAVLLLTDPAPDLLSYVRK 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 310 TLIGLpfNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDM-NTPNAPLHYYETVRMAAikESWTHNIQREKEFLRK 388
Cdd:cd19952   117 RLEKL--GLKSFFGGNAPSSGLLAVLLALQLCDSVDLYGFGVDSgHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRA 192


                  .
gi 1720407994 389 L 389
Cdd:cd19952   193 L 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 106-396 6.11e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 146.63  E-value: 6.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 106 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTKeYRLTPALDSLH-----CRRCIIVGNGGVLANKSLGSR 176
Cdd:cd23964    24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLN-LTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 177 IDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVPFPSKA 253
Cdd:cd23964   103 IDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 254 KCRqcqvgseqeRRQKSGPDAQsasdgfwksvATRVpkeppeiRILNPYFIQEAaftliglpFNNGL-MGRGNIPTLGSV 332
Cdd:cd23964   183 GKR---------PPPLFGPKLN----------ATNV-------RLLHPDFIRYL--------FNRWLnSSTSYRPTTGAL 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 333 AVTMALHGCDEVAVAGFGYDmntPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVIT 396
Cdd:cd23964   229 MLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 155-396 9.83e-36

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 132.02  E-value: 9.83e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 233
Cdd:cd23966    76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 234 DFKWLKyivykervpfpskakcrqcqvgseqerrqksgpdaqSA-SDGFWKSVATRVPK----EPPEIRILNPYFIQEAA 308
Cdd:cd23966   151 DLQWLI------------------------------------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVH 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 309 FTLIGlpfnnglmGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNtpNAPLHYYETVRmAAIKESWT--HNIQREKEFL 386
Cdd:cd23966   195 DNWTE--------HHGRYPSTGFLALIFALHICDEVSVFGFGADSK--GNWHHYWEKNR-SAGAFRKTgvHDADFESDII 263

                         250
                  ....*....|
gi 1720407994 387 RKLVKARVIT 396
Cdd:cd23966   264 KKLAKEGKIR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 110-364 1.52e-25

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 104.58  E-value: 1.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 110 DDSFRKWARIREFVPPfgiKGQDNLIKAILSVTK-EYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNS 188
Cdd:cd23980    37 EDTYKWWLRLQREKKP---KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 189 APVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWLKYIVYKER-----VPFPSKAKCRQcqvgse 263
Cdd:cd23980   114 APTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVISATTTGTishtyVPVPRKIKVKK------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 264 qerrqksgpdaqsasdgfwksvatrvpkepPEIRILNPYFIQEAaftliglpFNNGLMGRGNIPTLGSVAVTMALHGCDE 343
Cdd:cd23980   184 ------------------------------EKILIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHVCDE 225

                         250       260
                  ....*....|....*....|.
gi 1720407994 344 VAVAGFGYDmnTPNAPLHYYE 364
Cdd:cd23980   226 VDLYGFGAD--SKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 152-395 1.11e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 99.56  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 152 DSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 231
Cdd:cd23979    76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 232 WQDFKWLKYIVYKERVPFpSKAKCRQcqvgseqerrqksgpdaqsasdgfwksvATRVPKEppEIRILNPYFiqeaaFTL 311
Cdd:cd23979   152 TLDLLWITSALSTGQIRF-TYAPVKQ----------------------------FLRVDKD--KVQIYNPAF-----FKY 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 312 IglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmNTPNAPlHYYETVRMAA-IKESWTHNIQREKEFLRKLV 390
Cdd:cd23979   196 I---HDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLA 270


                  ....*
gi 1720407994 391 KARVI 395
Cdd:cd23979   271 KAGKI 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 157-389 3.45e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 89.25  E-value: 3.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFVLAG 229
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVWDP 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 230 FKWQD--FKWLkyivYKERVPFPSKAkcrqcqvgseQERRQksgpdaqsasdgfwksvatRVPKEPPEirILNPYF---- 303
Cdd:cd23968   125 SSYNVnlEKWY----KKPDFDFFPNY----------IKYRR-------------------RHPEEPFY--LIDPRFlwrl 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 304 ---IQEAAFTliglpfnnglMGRGNIPTLGSVAVTMALHGCDEVAVagfgYDMNTPNAP---LHYYETVRMAAIKESWTH 377
Cdd:cd23968   170 wdiLQEYTPE----------KIKPNPPSSGFIGIVLMLHLCDWVDV----YEYVPSVRQtdrCHYYDVEKDLACTLGAWH 235

                         250
                  ....*....|..
gi 1720407994 378 NIQREKEFLRKL 389
Cdd:cd23968   236 PLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 107-395 1.34e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 88.65  E-value: 1.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 107 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLHCRRCIIVGNGGVLANKSLGSRI 177
Cdd:cd23973    25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 178 DDYDIVIRLNSAPVKGFERDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKYIVYKE 245
Cdd:cd23973   105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEALLKNK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 246 RVPfpskakcrqcqVGSEQERRQKSGPDAQSASDGFWksVAtrvpkEPPEIRILNPYFIQeaAFTLiglpfnNGLMGRGN 325
Cdd:cd23973   183 TIP-----------SGAYYGRRPRSYFSGDFTEDKYL--VL-----HPDFLRYVKNRFLR--SKTL------KGKYWAIY 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 326 IPTLGSVAVTMALHGCDEVAVAGF---GYDmntpNAPLHYYETvrmaaikeSWT-------HNIQREKEFLRKLVKARVI 395
Cdd:cd23973   237 RPTTGAFLLLTALHLCDTVSAYGFiteDYR----KYPDHYYDK--------KKTklvfyinHDFRLEKKLWKRLHDEKII 304
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 157-389 2.11e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 87.32  E-value: 2.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTL------RITYPEGAMQRPEQYERdslFVlagf 230
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsILKRRYNSLKKNRDRDK---FL---- 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 231 kwQDFKWLK--YIVYkervPFPSKAKCRQcqvgseqerrqksgpdaqsasdgFWKSVATRVPKEPPEIRIL--NP-YFIQ 305
Cdd:cd23963   137 --NRLKEYNgsILWY----PKFSFKSSTN-----------------------LLLKAARALKKNGLNLTVVysNPeHFLA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 306 EAAFtliglpfnNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYEtvRMAAIKESWTHNIQRE 382
Cdd:cd23963   188 VQKF--------WKRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEE 257


                  ....*..
gi 1720407994 383 KEFLRKL 389
Cdd:cd23963   258 FKLLREL 264
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 116-395 2.69e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 84.88  E-value: 2.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 116 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDSLH-CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAP 190
Cdd:cd23972    37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTPGkCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 191 VKGFERDVGSKTTLR-----------ITYPEGAMQRPEQyERDSLFVLAGFKWQDFKWLKYIVykERVPFPSKAkcrqcq 259
Cdd:cd23972   117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAI--LGVPVPEGL------ 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 260 vgSEQERRQKS-GPDAQsasdgfwksvatrvpkePPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMAL 338
Cdd:cd23972   188 --DKGDRPHKYfGPEAS-----------------AKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTAL 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720407994 339 HGCDEVAVAGFGYDmNTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKLVKARVI 395
Cdd:cd23972   249 HTCDQVSAYGFITS-NYWKFSDHYYERKKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 156-207 3.89e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 82.68  E-value: 3.89e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRIT 207
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 156-396 6.13e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 77.87  E-value: 6.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLrITYPEGAMqrpeqyeRDSLFVLAGFKWQDF 235
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSF-YTFSTNTL-------MNSLRAYAGVGFNGP 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVY-----KERVPFPSKAKCRQCQVgseqERrqksGPDA-QSASDGFWKSVATRvpkeppEIRILNPYFIQEAAF 309
Cdd:cd23974   156 PQSKETRYiflpdHDRDYLLVKAALTHTPI----DR----GRDKsKRPSKYFGKDVTAE------KFKIYHPDFIRYLRN 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 310 TLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFgydmNTPNAPL---HYYETVRMAAIKESwTHNIQREKEFL 386
Cdd:cd23974   222 RFLWSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLW 296

                         250
                  ....*....|
gi 1720407994 387 RKLVKARVIT 396
Cdd:cd23974   297 QKLHKAGLIK 306
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 148-389 4.94e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 74.76  E-value: 4.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 148 TPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE------GAMQRPEQYER 221
Cdd:cd23969    56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 222 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVP----FPSkakcrqcqvgseqerrqksgPDAQSASDGFWKS 284
Cdd:cd23969   136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNvktaYPP--------------------LRLNHAIRGYWLT 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 285 VATRVPKeppeirilnpyfiqeaaftliglpfnnglmgrgniPTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLH 361
Cdd:cd23969   196 TKFRIKR-----------------------------------PSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYH 240

                         250       260
                  ....*....|....*....|....*...
gi 1720407994 362 YYETVRMAAikESWTHNIQREKEFLRKL 389
Cdd:cd23969   241 YYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 124-206 3.45e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.18  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 124 PPFGIKGQDNLIKAIlsvtkeyrltpALDSLHC---RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGS 200
Cdd:cd23986    25 APFSALGWEKYVPKI-----------PLSKLHLrgfRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGN 93


                  ....*.
gi 1720407994 201 KTTLRI 206
Cdd:cd23986    94 KTTIRI 99
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 156-368 3.83e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 71.43  E-value: 3.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 229
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 230 fkwqdfkwlkyivykervpfPSKakcrqcqvgseQERRQKSGPDAQsasdgfwksVATRVPKEPPEIRIlnpYFIQEAAF 309
Cdd:cd23977    81 --------------------PER-----------NMDRDGGGKTYR---------ALLTLAKMYPHLQV---YTLTEEKM 117

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720407994 310 TLIGLPFNN----GLMGRGNIPTLGSVAVTMALHGCDEVAVAG-----FGYDMNTPNAPLHYYETVRM 368
Cdd:cd23977   118 AYCDGVFQNetgkNRMKSGSFLSTGWFTMILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 155-225 4.80e-14

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 71.66  E-value: 4.80e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720407994 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPE-QYERDSLF 225
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLY 114
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 145-204 7.94e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 71.27  E-value: 7.94e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720407994 145 YRLTPA---LDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTL 204
Cdd:cd23970    54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL 116
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 145-215 2.16e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.89  E-value: 2.16e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 145 YRLTPALDSL---HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLrITYPEGAMQR 215
Cdd:cd23987    50 YELLPRTSPLknkHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSVVQR 122
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 154-215 1.07e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 64.50  E-value: 1.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720407994 154 LHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITyPEGAMQR 215
Cdd:cd23976    13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQR 73
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 158-204 9.59e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 61.89  E-value: 9.59e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720407994 158 RCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKgFERDVGSKTTL 204
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL 111
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 157-204 1.83e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 61.31  E-value: 1.83e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720407994 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKG-FERDVGSKTTL 204
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL 113
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 156-206 2.37e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 2.37e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI 206
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 156-367 1.48e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 57.64  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLAG 229
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 230 -FK--WQDFKWLKYIVYKERVPFPSKAKcrqcqVGSEQERRqksgpdaQSASDGFWKsvatrvpKEPPEIRILNPYFIQE 306
Cdd:cd23975    81 pFRnmRKDGKGIVYNMLKKAVESYPQAK-----IYVTTEKR-------MSYCDTVFK-------KETGKDRVQSGSYLST 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720407994 307 AAFTLIglpfnnglmgrgniptlgsvavtMALHGCDEVAVAGFGYDMNTPN-----APLHYYETVR 367
Cdd:cd23975   142 GWFTLI-----------------------LAMDACYGIHVYGMINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 145-215 7.23e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 56.50  E-value: 7.23e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720407994 145 YRLTPALDSLHCRR---CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLrITYPEGAMQR 215
Cdd:cd23988    50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDF-ITMNPSVVQR 122
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 157-204 1.43e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 52.53  E-value: 1.43e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720407994 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTL 204
Cdd:cd23989    64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL 112
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 157-367 1.53e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 49.45  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTLRITYPEGAMQRPEQYErdslfvlagfKWQDF 235
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLE----------KWRRP 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720407994 236 KWLKYIVYKE-RVPFPSKAKCRQCQVGSEqerrqksgpdAQSASDGFwksvatrvpKEPPEIRILNP-YFIQEAAFTLig 313
Cdd:cd23990   135 FYEVLQVYENaSVVLPAFYNTRNTDVSIR----------VKYVLDDF---------ESQQAVYYFHPqYLLNVSRFWL-- 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720407994 314 lpfNNGLmgRGNIPTLGSVAVTMALHGCDEVAVAGF-GYDMNTPNAPL--HYYETVR 367
Cdd:cd23990   194 ---RQGV--RAKRISSGLMLVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNVK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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