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Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [ Mus musculus (house mouse) ]

Gene ID: 20354, updated on 2-Nov-2024

Summary

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Official Symbol
Sema4dprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Dprovided by MGI
Primary source
MGI:MGI:109244
See related
Ensembl:ENSMUSG00000021451 AllianceGenome:MGI:109244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD100; Semaj; Semcl2; coll-4; Semacl2
Summary
Enables receptor ligand activity and semaphorin receptor binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of Rho protein signal transduction; and regulation of peptidyl-tyrosine phosphorylation. Acts upstream of or within positive regulation of axonogenesis. Located in extracellular space. Part of semaphorin receptor complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA4D (semaphorin 4D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 32.3), spleen adult (RPKM 22.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Sema4d in Genome Data Viewer
Location:
13 A5; 13 26.16 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (51839565..51947823, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51685529..51793678, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 Neighboring gene predicted gene, 22806 Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene STARR-seq mESC enhancer starr_34521 Neighboring gene STARR-positive B cell enhancer ABC_E11544 Neighboring gene STARR-positive B cell enhancer ABC_E4068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51862969-51863152 Neighboring gene predicted gene, 19281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51896377-51896617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51909396-51909586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51941838-51941947 Neighboring gene growth arrest and DNA-damage-inducible 45 gamma Neighboring gene VISTA enhancer mm1565 Neighboring gene STARR-seq mESC enhancer starr_34529 Neighboring gene STARR-seq mESC enhancer starr_34531 Neighboring gene predicted gene, 26651

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity. Zhu Z, et al. Mol Immunol, 2016 Oct. PMID 27614265
  2. Negative regulation of dendritic cell activation in psoriasis mediated via CD100-plexin-B2. Xiao C, et al. J Pathol, 2020 Apr. PMID 31943215
  3. Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Yukawa K, et al. Int J Mol Med, 2010 Jul. PMID 20514420
  4. Control of bone resorption by semaphorin 4D is dependent on ovarian function. Dacquin R, et al. PLoS One, 2011. PMID 22046317, Free PMC Article
  5. CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis. Zhang C, et al. Cancer Lett, 2019 Jul 28. PMID 30981760

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.
    Title: Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.
  2. Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-kappaB/NLRP3 pathways.
    Title: Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-κB/NLRP3 pathways.
  3. CD100 boosts the inflammatory response in the challenge phase of allergic contact dermatitis in mice.
    Title: CD100 boosts the inflammatory response in the challenge phase of allergic contact dermatitis in mice.
  4. Sema4D is diminished in leukocyte platelet-rich fibrin and impairs pre-osteoblastic MC3T3-E1 cells' functionality.
    Title: Sema4D is diminished in leukocyte platelet-rich fibrin and impairs pre-osteoblastic MC3T3-E1 cells' functionality.
  5. Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression.
    Title: Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression.
  6. Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.
    Title: Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.
  7. Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway.
    Title: Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway.
  8. Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.
    Title: Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.
  9. Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint.
    Title: Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint.
  10. Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model.
    Title: Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bone trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte aggregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ossification involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ossification involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of collateral sprouting ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of inhibitory synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
part_of semaphorin receptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
semaphorin-4D
Names
M-sema G
sema J
semaphorin H
semaphorin-C-like 2
semaphorin-J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281880.2 → NP_001268809.1  semaphorin-4D isoform 1 precursor

    See identical proteins and their annotated locations for NP_001268809.1

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Consensus CDS
    CCDS26514.1
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Related
    ENSMUSP00000105667.3, ENSMUST00000110040.9
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  2. NM_001378313.1 → NP_001365242.1  semaphorin-4D isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  3. NM_001378314.1 → NP_001365243.1  semaphorin-4D isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  4. NM_001378315.1 → NP_001365244.1  semaphorin-4D isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  5. NM_001378316.1 → NP_001365245.1  semaphorin-4D isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Related
    ENSMUSP00000105666.2, ENSMUST00000110039.2
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  6. NM_001378317.1 → NP_001365246.1  semaphorin-4D isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  7. NM_001378318.1 → NP_001365247.1  semaphorin-4D isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  8. NM_001378319.1 → NP_001365248.1  semaphorin-4D isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  9. NM_001378320.1 → NP_001365249.1  semaphorin-4D isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  10. NM_001378321.1 → NP_001365250.1  semaphorin-4D isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  11. NM_001378322.1 → NP_001365251.1  semaphorin-4D isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  12. NM_001378323.1 → NP_001365252.1  semaphorin-4D isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126547
    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  13. NM_001378324.1 → NP_001365253.1  semaphorin-4D isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Conserved Domains (2) summary
    cd11259
    Location:31 → 499
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:501 → 546
    PSI; Plexin repeat

  14. NM_001378325.1 → NP_001365254.1  semaphorin-4D isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126547
    UniProtKB/TrEMBL
    D3Z3P4
    Related
    ENSMUSP00000105669.3, ENSMUST00000110042.3
    Conserved Domains (2) summary
    cd00096
    Location:63 → 71
    Ig; Ig strand B [structural motif]
    cl11960
    Location:55 → 139
    Ig; Immunoglobulin domain

  15. NM_013660.5 → NP_038688.2  semaphorin-4D isoform 1 precursor

    See identical proteins and their annotated locations for NP_038688.2

    Status: VALIDATED

    Source sequence(s)
    AC126247, AC126547
    Consensus CDS
    CCDS26514.1
    UniProtKB/Swiss-Prot
    O09126, Q6GTM9
    UniProtKB/TrEMBL
    Q8BJC1
    Related
    ENSMUSP00000021900.8, ENSMUST00000021900.14
    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    51839565..51947823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157947.1 → XP_036013840.1  semaphorin-4D isoform X3

    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  2. XM_036157945.1 → XP_036013838.1  semaphorin-4D isoform X1

    Conserved Domains (4) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat
    cd00096
    Location:569 → 577
    Ig; Ig strand B [structural motif]
    cl11960
    Location:563 → 646
    Ig; Immunoglobulin domain

  3. XM_036157946.1 → XP_036013839.1  semaphorin-4D isoform X2

    Conserved Domains (2) summary
    cd11259
    Location:31 → 501
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    pfam01437
    Location:503 → 548
    PSI; Plexin repeat

  4. XM_036157948.1 → XP_036013841.1  semaphorin-4D isoform X4

    UniProtKB/TrEMBL
    D3Z3P4
    Conserved Domains (2) summary
    cd00096
    Location:63 → 71
    Ig; Ig strand B [structural motif]
    cl11960
    Location:55 → 139
    Ig; Immunoglobulin domain

RNA

  1. XR_004938006.1 RNA Sequence

  2. XR_004938005.1 RNA Sequence

  3. XR_004938004.1 RNA Sequence

  4. XR_004937990.1 RNA Sequence

  5. XR_004937993.1 RNA Sequence

  6. XR_004937991.1 RNA Sequence

  7. XR_004937992.1 RNA Sequence

  8. XR_004937995.1 RNA Sequence

  9. XR_004937994.1 RNA Sequence

  10. XR_004938007.1 RNA Sequence

  11. XR_004938003.1 RNA Sequence

  12. XR_004938000.1 RNA Sequence

  13. XR_004937986.1 RNA Sequence

  14. XR_004937988.1 RNA Sequence

  15. XR_004937987.1 RNA Sequence

  16. XR_004937989.1 RNA Sequence

  17. XR_004938001.1 RNA Sequence

  18. XR_004937999.1 RNA Sequence

  19. XR_004937996.1 RNA Sequence

  20. XR_004938002.1 RNA Sequence

  21. XR_004937997.1 RNA Sequence

  22. XR_004937998.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09126.2 GenPept UniProtKB/Swiss-Prot:O09126

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