5L59,5L5L,5B4W,5L59,3NVQ,1OLZ,6QP9


Conserved Protein Domain Family
PSI
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pfam01437: PSI (this model, PSSM-Id:396154 is obsolete and has been replaced by 396154)
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Plexin repeat
A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Links
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Statistics
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PSSM-Id: 396154
Aligned: 95 rows
Threshold Bit Score: 30.7542
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5L59_A  479 SCVQYTSCEL-CLGsrdPHCGWCVLHSICSR-QDACe-RAEEPQRFASDLLQ------CV 529  house mouse
Q9NPR2  525 NCSLYRSCGD-CLLardPYCAWS--GSSCKH-VSLY---QPQLATRPWIQDIe----gAS 573  human
Q62179  512 NCSLYPTCGD-CLLardPYCAWT--GSACRL-ASLY---QPDLASRPWTQDIe----gAS 560  house mouse
O09126  502 FCEKHGSCED-CVLardPYCAWSPAIKACVTl------HQEEASSRGWIQDMsgdtssCL 554  house mouse
1OLZ_A  481 FCGKHGTCED-CVLardPYCAWSPPTATCVAl------HQTESPSRGLIQEMsgdasvCP 533  human
Q9BXR8  530 RCQQYSGCMKnCIGsqdPYCGWAP-DGSCIF--------LSPGTRAAFEQDVsgastsgl 580  human
Q8NFY4  514 RCERYGSCKKsCIAsrdPYCGWLS-QGSCGRvTPGMlaEGYEQDTEFGNTAHlg---dCH 569  human
Q76KF0  514 RCERYGSCKKsCIAsrdPYCGWLS-QGVCERvTLGMlpGGYEQDTEYGNTAHlg---dCH 569  house mouse
Q8BKG8  514 RCERYGSCKKsCIAsrdPYCGWLSQGV-CERvTLGMlpGGYEQDTEYGNTAHlg---dCH 569  house mouse
Q9NTN9  507 SCSRYRSCYD-CILardPYCGWDPGTHACAAa------TTIANRTALIQDIErgn-rgCE 558  human
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