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ENDOG endonuclease G [ Homo sapiens (human) ]

Gene ID: 2021, updated on 13-Apr-2024

Summary

Official Symbol
ENDOGprovided by HGNC
Official Full Name
endonuclease Gprovided by HGNC
Primary source
HGNC:HGNC:3346
See related
Ensembl:ENSG00000167136 MIM:600440; AllianceGenome:HGNC:3346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 10.6), prostate (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See ENDOG in Genome Data Viewer
Location:
9q34.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128818500..128822676)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (141023301..141027477)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131580779..131584955)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zyg-11 related cell cycle regulator Neighboring gene uncharacterized LOC124902282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131534571-131535297 Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20352 Neighboring gene TBC1 domain family member 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131574071-131574244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131581177-131581742 Neighboring gene KYAT1-SPOUT1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131590537-131591467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29093 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131592801-131593024 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131600611-131601111 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131607420-131607646 Neighboring gene kynurenine aminotransferase 1 Neighboring gene Sharpr-MPRA regulatory region 9337 Neighboring gene Sharpr-MPRA regulatory region 7409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131647725-131648487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131654523-131655130 Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29095 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131666020-131666192 Neighboring gene uncharacterized LOC101929291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131672021-131672804

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced neurotoxicity is associated with the activation of a pathway involving endonuclease G PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ27463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA recombination TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
endonuclease G, mitochondrial
Names
endo G
mitochondrial endonuclease G
NP_004426.2
XP_011516649.2
XP_054218231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046991.1 RefSeqGene

    Range
    5090..9266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004435.2NP_004426.2  endonuclease G, mitochondrial precursor

    See identical proteins and their annotated locations for NP_004426.2

    Status: REVIEWED

    Source sequence(s)
    BC004922, BC016351, X79444
    Consensus CDS
    CCDS6912.1
    UniProtKB/Swiss-Prot
    Q14249, Q5T281, Q9BSP2
    UniProtKB/TrEMBL
    E5KNL5
    Related
    ENSP00000361725.4, ENST00000372642.5
    Conserved Domains (1) summary
    smart00477
    Location:78284
    NUC; DNA/RNA non-specific endonuclease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128818500..128822676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518347.3XP_011516649.2  endonuclease G, mitochondrial isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    141023301..141027477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362256.1XP_054218231.1  endonuclease G, mitochondrial isoform X1