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ENDOG endonuclease G [ Homo sapiens (human) ]

Gene ID: 2021, updated on 5-Jan-2022

Summary

Official Symbol
ENDOGprovided by HGNC
Official Full Name
endonuclease Gprovided by HGNC
Primary source
HGNC:HGNC:3346
See related
Ensembl:ENSG00000167136 MIM:600440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 10.6), prostate (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See ENDOG in Genome Data Viewer
Location:
9q34.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128818402..128822676)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131580779..131584955)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033 Neighboring gene TBC1 domain family member 13 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene kynurenine aminotransferase 1 Neighboring gene Sharpr-MPRA regulatory region 7409 Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC101929291

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced neurotoxicity is associated with the activation of a pathway involving endonuclease G PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endodeoxyribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination TAS
Traceable Author Statement
more info
PubMed 
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron death in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endonuclease G, mitochondrial
Names
endo G
mitochondrial endonuclease G
NP_004426.2
XP_011516649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046991.1 RefSeqGene

    Range
    5090..9266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004435.2NP_004426.2  endonuclease G, mitochondrial precursor

    See identical proteins and their annotated locations for NP_004426.2

    Status: REVIEWED

    Source sequence(s)
    BC004922, BC016351, X79444
    Consensus CDS
    CCDS6912.1
    UniProtKB/Swiss-Prot
    Q14249
    UniProtKB/TrEMBL
    E5KNL5
    Related
    ENSP00000361725.4, ENST00000372642.5
    Conserved Domains (1) summary
    smart00477
    Location:78284
    NUC; DNA/RNA non-specific endonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128818402..128822676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518347.2XP_011516649.1  endonuclease G, mitochondrial isoform X1

    Conserved Domains (1) summary
    smart00477
    Location:167295
    NUC; DNA/RNA non-specific endonuclease
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