2XRG,1ZM8,1QL0


Conserved Protein Domain Family
NUC

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smart00477: NUC 
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DNA/RNA non-specific endonuclease
prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases
Statistics
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PSSM-Id: 214683
Aligned: 20 rows
Threshold Bit Score: 189.494
Threshold Setting Gi: 45384326
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XRG_A       614 HTDFESGYSEIFLMPLWTSYTISKQ-------AEVSSi---------------PEHLTNCVRPDVRVSP-GFSQNCLAYK 670 Norway rat
NP_594598     78 NHGYMSVFDRRTRNPFYTAETITQE-------SLNQRk---------------GNRRYSEFVPDDNIPE-MFQAKLGDYR 134 Schizosaccharom...
P81204        90 RSGYILSYNRRDRLAHWVGEHLTSA-------SLQAGq--------------gVDRDKSNFQEDTDIPE-MFRAHLKDYV 147 Syncephalastrum...
YP_227663     62 KNQYALSYNNSKGTANWVAWQLNSS-------WLGNA------------------ERQDNFRPDKTLPAgWVRVTPSMYS 116 Nostoc sp. PCC ...
NP_443847    420 HFSVVLNANPKRKMAFYTAVNIDGA-------RWTN-----------------LERGNDVWFYDPRIPE-ELQNGDELYG 474 Rhizobium sp. N...
YP_002374925  74 kkhYTLGYAESARQSEWTAYPLKREmvelaltLLKSK----------------KIKRSTKFFEDTNIKG-AF-PKLEDYF 135 Borrelia burgdo...
1313264A      46 RHAYTLNNNSTTKFANWVAYHITKD-------TPASG-------------------KTRNWKTDPALNP-ADTLAPADYT 98  Serratia marces...
NP_224013     74 NNFYSVCYSSELKNPIYGVSVLFGD-------LVDKN----------------NIEKRYEFKPDTRLAE-YQQAVTQDYT 129 Helicobacter py...
AAB03265     135 YKGFVSSLNYERRIPNWVLEYIPGT-------TTAADsvvtadndlvnasaaeAQRDGMRFFADMTVPQ-LFRVQPGDYI 206 Trypanosoma brucei
1ZM8_A        47 KNQYALSYNNSKGTANWVAWQLNSS-------WLGNA------------------ERQDNFRPDKTLPAgWVRVTPSMYS 101 Anabaena sp.
2XRG_A       671 N------D----Kq------MSYGFLFPPYL-SSS-----PEAKYDAFLVT-NMVPMYP-A-FKRV---WAYFQRVLVKK 722 Norway rat
NP_594598    135 G------S----G-------YDRGHQVPAADcKFS-----QEAMNETFYLS-NMCPQVG-DgFNRNy--WAYFEDWCRRL 188 Schizosaccharom...
P81204       148 S------S----G-------YDRGHQAPAADdLSS-----QEAMDETFLLS-NMAPQVGvG-FNRHy--WAYLEGFMRDL 201 Syncephalastrum...
YP_227663    117 G------S----G-------YDRGHIAPSADrTKT-----TEDNAATFLMT-NMMPQTP-D-NNRNt--WGNLEDYCREL 169 Nostoc sp. PCC ...
NP_443847    475 DepvpskN----Y-------FDRGHLVRRLDpVWGeirvaKQANDDTFQWT-NCSPQYW-G-FNQGadlWQGLENFLLYN 540 Rhizobium sp. N...
YP_002374925 136 K------S----G-------YDRGHIVSSADmSFS-----ENAMKDTYFLS-NMSPQKS-E-FNSGi--WLKLEKLVREW 188 Borrelia burgdo...
1313264A      99 G------AnaalK-------VDRGHQAPLASlA-G-----VSDWESLNYLS-NITPQKS-D-LNQGa--WARLEDQERKL 154 Serratia marces...
NP_224013    130 R------S----G-------FDRGHFVANDAsFDFa----SNPLRETYRMT-NITPEAK-N-TNRHs--VLLVEKEGRNL 183 Helicobacter py...
AAB03265     207 G------G----GrgqdsrgLSRGHLAAAQFhKSS-----TVELAQTFNMNaNTVPQDM-T-MNAVd--WLRLENLTRKL 267 Trypanosoma brucei
1ZM8_A       102 G------S----G-------YARGHIAPSADrTKT-----TEDNAATFLMT-NMMPQTP-D-NNRNt--WGNLEDYCREL 154 Anabaena sp.
2XRG_A       723 YASe-RNGVNVISGPIFDYNYDGLRD----------------------------------------Te--dE--IKQYVE 757 Norway rat
NP_594598    189 TSk--YGSVTIMTGPLYLPKKNERGQw--------------------------------------------E--VQYRVI 220 Schizosaccharom...
P81204       202 TQn--FTDVYVYTGPLFLPSAASTGR----------------------------------------KnpayS--IEYPFL 237 Syncephalastrum...
YP_227663    170 VSq--GKELYIVAGPNGSLGKPLKGKv--------------------------------------------T--VPKSTW 201 Nostoc sp. PCC ...
NP_443847    541 TDDe-NVQASVFSGPLFRADDEEHRG----------------------------------------Il---IpqFFWKVI 576 Rhizobium sp. N...
YP_002374925 189 AISk--GYIYIISAGILTENKGF--------------------------------------------------------I 210 Borrelia burgdo...
1313264A     155 IDRadISSVYTVTGPLYERDMGKLPG----------------------------------------T------------- 181 Serratia marces...
NP_224013    184 ARk--YHQVLVEELTIIKQGYRTFS------------------------------------------------------- 206 Helicobacter py...
AAB03265     268 RRYy-ERGLWVVTGPVFHPRLVDGDVrtwrwaepsqcpspvkpvssgvlasgehchcgndkaavhlRk---I--VCYELV 341 Trypanosoma brucei
1ZM8_A       155 V-Sq-GKELYIVAGPNGSLGKPLKGKv--------------------------------------------T--VPKSTW 186 Anabaena sp.
2XRG_A       758 G--S-SIP-VPTHYYSIITSCLDftqpadkcDG-P--LSVSSFILPHRPDNDESCnssedeskwveelMKMHTARVRDIE 830 Norway rat
NP_594598    221 Gn-PpNVA-VPTHFFKVIIAEKSge-----pTS-S--PSVAAFVLPNKPIADNFP-------------LKNFAVPVEVVE 277 Schizosaccharom...
P81204       238 GatTpNVP-VPTHFFKIALTTTA--------SS-E--YALGAFVLPNQAIDSSTP-------------LTNFKVELEAIE 292 Syncephalastrum...
YP_227663    202 K--IvVVLdSPGSGLEGITANT----------------RVIAVNIPNDPELNN-D-------------WRAYKVSVDELE 249 Nostoc sp. PCC ...
NP_443847    577 AvtDkNDR-LYTSGYMVSQQDYA--------------LDIPFERLPVGPNSTK-P-------------GQNFQVPVAKII 627 Rhizobium sp. N...
YP_002374925 211 G--KnKIL-IPKNFYKIVLAINN--------NN-Y--YDIISFIIPNEKAKDL-D-------------LENYVVSVDLIE 262 Borrelia burgdo...
1313264A     182 ---QkAHT-IPSAYWKVIFINNS--------PAvN--HYAAFLFDQNTPKGA--D-------------FCQFRVTVDEIE 232 Serratia marces...
NP_224013    207 ---SkNIA-IPSGFWYHYDTSLT--------DS-YenAKSECFYIPNDNQKY--P-------------LQEMRRDCKEYE 258 Helicobacter py...
AAB03265     342 G--KrDVA-VPTHLFKVILGERA--------DG-A--HEAAAFLMPNEPIAVERP-------------LTAYQVPVVEIE 394 Trypanosoma brucei
1ZM8_A       187 K--IvVVLdSPGSGLEGITANT----------------RVIAVNIPNDPELNN-D-------------WRAYKVSVDELE 234 Anabaena sp.
2XRG_A       831 HLTGLDFYRKTSR 843 Norway rat
NP_594598    278 RASGLEILSNVPk 290 Schizosaccharomyces pombe 972h-
P81204       293 KAAGLVFFDKLDR 305 Syncephalastrum racemosum
YP_227663    250 SLTGYDFLSNVSP 262 Nostoc sp. PCC 7120
NP_443847    628 EDTGIVFADEILS 640 Rhizobium sp. NGR234
YP_002374925 263 KKTKIDFFEKLDS 275 Borrelia burgdorferi ZS7
1313264A     233 KRTGLIIWAGLPD 245 Serratia marcescens
NP_224013    259 RVEKQVVFKNNKN 271 Helicobacter pylori J99
AAB03265     395 RLTGLEFFRNVAA 407 Trypanosoma brucei
1ZM8_A       235 SLTGYDFLSNVSP 247 Anabaena sp.
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