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ZSCAN4 zinc finger and SCAN domain containing 4 [ Homo sapiens (human) ]

Gene ID: 201516, updated on 23-Nov-2021

Summary

Official Symbol
ZSCAN4provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23709
See related
Ensembl:ENSG00000180532 MIM:613419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF494
Summary
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZSCAN4 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57651476..57679152)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58162844..58190512)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 134 Neighboring gene zinc finger protein 211 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 551 Neighboring gene zinc finger protein 154

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35105, MGC126787, MGC126789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of mitotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 4
Names
zinc finger protein 494

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384833.1NP_001371762.1  zinc finger and SCAN domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AC003682, AC004017
    Related
    ENST00000683825.1
    Conserved Domains (4) summary
    cd07936
    Location:40124
    SCAN; SCAN oligomerization domain
    sd00017
    Location:342362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:368390
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:382407
    zf-H2C2_2; Zinc-finger double domain
  2. NM_152677.4NP_689890.1  zinc finger and SCAN domain-containing protein 4

    See identical proteins and their annotated locations for NP_689890.1

    Status: VALIDATED

    Source sequence(s)
    AC004017
    Consensus CDS
    CCDS12958.1
    UniProtKB/Swiss-Prot
    Q8NAM6
    Related
    ENSP00000321963.4, ENST00000318203.9
    Conserved Domains (4) summary
    cd07936
    Location:40124
    SCAN; SCAN oligomerization domain
    sd00017
    Location:342362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:368390
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:382407
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57651476..57679152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026458.1XP_016881947.1  zinc finger and SCAN domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8NAM6
    Conserved Domains (4) summary
    cd07936
    Location:40124
    SCAN; SCAN oligomerization domain
    sd00017
    Location:342362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:368390
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:382407
    zf-H2C2_2; Zinc-finger double domain
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