1Y7Q,2FI2


Conserved Protein Domain Family
SCAN

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cd07936: SCAN 
Click on image for an interactive view with Cn3D
SCAN oligomerization domain
The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.
Statistics
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PSSM-Id: 153421
View PSSM: cd07936
Aligned: 29 rows
Threshold Bit Score: 96.5606
Threshold Setting Gi: 120969705
Created: 30-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:
  • Structure:1Y7Q: the SCAN domain of human ZNF174 forms a homodimer, contacts at 4 A
    View structure with Cn3D
  • Structure:2FI2: the SCAN domain of the human tumor suppressor protein MZF1 forms a homodimer, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ## ###    ### ##  ##  ## ####    ##  ##  ### ## ####                  #  
1Y7Q_A          8 PELCRQSFRRFCYqevsGPQEALSQLRQLCRQWLQPe-lHTKEQILELLVMEQFLTILPeEIQARVRHrcLMSSKEIVTL 86
gi 189527797  231 PETYRQRFRAMSTpageSPTESYHRLRTLYRRWVKPd-sHSKEEIGETIVLEQLLRVLPhEVRMWVKEhePTTGLEAAKL 309
gi 18157521   208 AETYRKRFRALDInpgeTPRELYVRLRELFNKWVKPe-aCTVKEISEKLILEQFLRMMNpEMEIWIRErdPQSAEEASRL 286
gi 189545810  186 AETYRLRFRALNTpsdeSPMELYVRLKDLFSKWVNFk-vSSKTNLMETMVLEQYMRVLYpEVRTWVKErdPVTAEEAAKL 264
gi 146328587   40 SEFSRMVLNSFQDsnnsYARQELQRLYRIFHSWLQPe-kHSKDEIISLLVLEQFMIGGHcNDKAGVKEkwKSSGKNLERF 118
gi 148231350   70 PEVYRRKFRALHKepmdSYSDAVSNLRTTFRQWIKGlsiETLADLEDLMVKDQFLHICPaEVRQFVVDrePKTADKAAEI 149
gi 194687130   38 LEVLRVRFRTFSSsdesDPINALRRLRELCGLWLRPd-lHTKEQMVDRLVLEQFVMCMPpDIQVLVKScgAETCKDLEEV 116
gi 197245685  439 PEIHRVKFRDMALkageTFNSFYQRLHYRYDRWMEAsdiKQFKDCYRPLVLEQLLQKCPaIVRQKVLKhkGCSPYQAAQI 518
gi 148706173   40 FHSPSVQFNVFPNnngsLAKQELQTLWEMFTSWLQPe-kQTKEQMISQLVLEQFLITGHcKDKYALTEkwKASGRNMERF 118
gi 189525908  694 RETYRQRFRSLEVehleSPKELYVRLKELYGKWMQPk-sKSIEEIGEVIILEQYLRMLSpELQVWVREhdPQSASQAATL 772

                  ....*.
Feature 1         ## ###
1Y7Q_A         87 VEDFHR 92
gi 189527797  310 AQQYIN 315
gi 18157521   287 AEVFLS 292
gi 189545810  265 VESYVA 270
gi 146328587  119 IEDLTD 124
gi 148231350  150 ADTYAA 155
gi 194687130  117 LRKKQK 122
gi 197245685  519 ADDHLH 524
gi 148706173  119 MESLTD 124
gi 189525908  773 ADVFVA 778

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