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KRTCAP3 keratinocyte associated protein 3 [ Homo sapiens (human) ]

Gene ID: 200634, updated on 21-Dec-2019

Summary

Official Symbol
KRTCAP3provided by HGNC
Official Full Name
keratinocyte associated protein 3provided by HGNC
Primary source
HGNC:HGNC:28943
See related
Ensembl:ENSG00000157992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCP3
Expression
Broad expression in colon (RPKM 15.6), small intestine (RPKM 13.3) and 22 other tissues See more
Orthologs

Genomic context

See KRTCAP3 in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27442366..27446481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27665233..27669348)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene nuclear receptor binding protein 1 Neighboring gene intraflagellar transport 172 Neighboring gene RNA, U6 small nuclear 986, pseudogene Neighboring gene fibronectin type III domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of keratinocyte associated protein 3 (KRTCAP3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126736, MGC126738

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratinocyte-associated protein 3
Names
keratinocytes associated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168364.1NP_001161836.1  keratinocyte-associated protein 3

    See identical proteins and their annotated locations for NP_001161836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AC074117, BC101689, BM794111, CB160871
    Consensus CDS
    CCDS1754.1
    UniProtKB/Swiss-Prot
    Q53RY4
    Related
    ENSP00000442400.1, ENST00000543753.5
    Conserved Domains (1) summary
    pfam12304
    Location:19206
    BCLP; Beta-casein like protein
  2. NM_001321325.2NP_001308254.1  keratinocyte-associated protein 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AY358993, BC143574
    Consensus CDS
    CCDS1754.1
    UniProtKB/Swiss-Prot
    Q53RY4
    Related
    ENSP00000384689.1, ENST00000407293.5
    Conserved Domains (1) summary
    pfam12304
    Location:19206
    BCLP; Beta-casein like protein
  3. NM_173853.4NP_776252.2  keratinocyte-associated protein 3

    See identical proteins and their annotated locations for NP_776252.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 - 3 encode the same protein.
    Source sequence(s)
    AY157576, BC101689
    Consensus CDS
    CCDS1754.1
    UniProtKB/Swiss-Prot
    Q53RY4
    Related
    ENSP00000288873.3, ENST00000288873.7
    Conserved Domains (1) summary
    pfam12304
    Location:19206
    BCLP; Beta-casein like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27442366..27446481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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