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DAND5 DAN domain BMP antagonist family member 5 [ Homo sapiens (human) ]

Gene ID: 199699, updated on 2-Aug-2020

Summary

Official Symbol
DAND5provided by HGNC
Official Full Name
DAN domain BMP antagonist family member 5provided by HGNC
Primary source
HGNC:HGNC:26780
See related
Ensembl:ENSG00000179284 MIM:609068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3
Summary
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 2.6), brain (RPKM 0.4) and 1 other tissue See more
Orthologs

Genomic context

See DAND5 in Genome Data Viewer
Location:
19p13.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12969618..12974753)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13080432..13085567)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 6515 Neighboring gene calreticulin Neighboring gene GADD45G interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC107985286 Neighboring gene VISTA enhancer hs1900

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • MGC126849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
morphogen activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogen activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
atrial septum development ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of heart left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of heart left/right asymmetry ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of left/right asymmetry in lateral mesoderm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nodal signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
sequestering of BMP in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of nodal from receptor via nodal binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction involved in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventricular septum development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DAN domain family member 5
Names
DAN domain family member 5, BMP antagonist
DAN domain family, member 5
cerberus 2
cerberus-like 2
cerberus-like protein 2
cerl-2
cysteine knot superfamily 1, BMP antagonist 3
gremlin-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152654.3NP_689867.1  DAN domain family member 5 precursor

    See identical proteins and their annotated locations for NP_689867.1

    Status: REVIEWED

    Source sequence(s)
    AC092069
    Consensus CDS
    CCDS12291.1
    UniProtKB/Swiss-Prot
    Q8N907
    Related
    ENSP00000323155.1, ENST00000317060.3
    Conserved Domains (1) summary
    cl21545
    Location:85185
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12969618..12974753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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