Dand5 DAN domain family member 5, BMP antagonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dand5provided by MGI
Official Full Name: DAN domain family member 5, BMP antagonistprovided by MGI
Primary source: MGI:MGI:1344365
See related: Ensembl:ENSMUSG00000053226 AllianceGenome:MGI:1344365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dte; coco; Cerl2; Cerr2; GREM3; Cerl-2
Summary: Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 13.6), cerebellum adult (RPKM 4.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 C3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85542034..85558894, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84815405..84832265, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
Title: Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
Cerl2 plays an important role during heart development.
Title: Targeted inactivation of Cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse.
The consequent prolonged Nodal activity in the node by the absence of Cerl2 affects local Nodal expression and prolongs its expression in the lateral plate mesoderm.
Title: The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.
Decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt-Cerl2 interlinked feedback loops.
Title: Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.
Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.
Title: Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.
cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.
Title: Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo.
Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side
Title: The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Dand5 gene: The Dand5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, and rat.
Orthologs from Annotation Pipeline: 191 organisms have orthologs with human gene Dand5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables morphogen activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables morphogen activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in atrial septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of heart left/right asymmetry	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nodal signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sequestering of BMP in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sequestering of nodal from receptor via nodal binding	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: DAN domain family member 5

Names: DAN domain family, member 5; cerberus-like protein 2; dante

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201227.3 → NP_957679.1 DAN domain family member 5 precursor

See identical proteins and their annotated locations for NP_957679.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and is the protein-coding transcript.

Source sequence(s)

AC155163, AK143395, AY387409

Consensus CDS

CCDS22477.1

UniProtKB/Swiss-Prot

Q76LW6

UniProtKB/TrEMBL

Q3UPN3

Related

ENSMUSP00000070057.5, ENSMUST00000065539.6

Conserved Domains (1) summary

cl21545
Location:81 → 181

GHB_like; Glycoprotein hormone beta chain homologues

RNA

NR_033145.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.

Source sequence(s)

AK143395, AY387409, BY248078

Related

ENSMUST00000238279.2