Format

Send to:

Choose Destination

ZNF627 zinc finger protein 627 [ Homo sapiens (human) ]

Gene ID: 199692, updated on 5-Nov-2017
Official Symbol
ZNF627provided by HGNC
Official Full Name
zinc finger protein 627provided by HGNC
Primary source
HGNC:HGNC:30570
See related
Ensembl:ENSG00000198551 MIM:612248; Vega:OTTHUMG00000182035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 7.4), endometrium (RPKM 6.4) and 25 other tissues See more
Orthologs
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (11575255..11619159)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11708235..11729974)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene elongation factor 1 homolog Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene vomeronasal 2 receptor 12 pseudogene Neighboring gene zinc finger protein 887, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ90365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290083.1NP_001277012.1  zinc finger protein 627 isoform 2

    See identical proteins and their annotated locations for NP_001277012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK074846, BC069232, DB043358, DB158202
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:142350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:345370
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001290084.1NP_001277013.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK074846, AK095639, BC069232, DB043358
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267292
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001290085.1NP_001277014.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK074846, BC069232, DA786363, DB043358
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267292
    zf-H2C2_2; Zinc-finger double domain
  4. NM_145295.3NP_660338.1  zinc finger protein 627 isoform 1

    See identical proteins and their annotated locations for NP_660338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK074846, BC069232, BC098416, DB043358
    Consensus CDS
    CCDS42502.1
    UniProtKB/Swiss-Prot
    Q7L945
    Related
    ENSP00000354414.4, OTTHUMP00000268172, ENST00000361113.9, OTTHUMT00000458875
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:174382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:377402
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    11575255..11619159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527780.2XP_011526082.1  zinc finger protein 627 isoform X1

    See identical proteins and their annotated locations for XP_011526082.1

    Conserved Domains (3) summary
    COG5048
    Location:142350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:345370
    zf-H2C2_2; Zinc-finger double domain

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    11708101..11729833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center