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ZNF627 zinc finger protein 627 [ Homo sapiens (human) ]

Gene ID: 199692, updated on 23-Nov-2023

Summary

Official Symbol
ZNF627provided by HGNC
Official Full Name
zinc finger protein 627provided by HGNC
Primary source
HGNC:HGNC:30570
See related
Ensembl:ENSG00000198551 MIM:612248; AllianceGenome:HGNC:30570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), endometrium (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF627 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11597483..11619161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11725009..11747346)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11708298..11729976)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11708237-11709235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10124 Neighboring gene MPRA-validated peak3358 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11734453-11734953 Neighboring gene vomeronasal 2 receptor 12 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10125 Neighboring gene zinc finger protein 887, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ90365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290083.2NP_001277012.1  zinc finger protein 627 isoform 2

    See identical proteins and their annotated locations for NP_001277012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC104527, AK074846, BC069232, DB158202
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:142350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:345370
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001290084.3NP_001277013.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK074846, AK095639, BC069232
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267292
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001290085.2NP_001277014.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC104527, AK074846, BC069232, DA786363
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267292
    zf-H2C2_2; Zinc-finger double domain
  4. NM_145295.4NP_660338.1  zinc finger protein 627 isoform 1

    See identical proteins and their annotated locations for NP_660338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC104527, AK074846, BC069232, BC098416
    Consensus CDS
    CCDS42502.1
    UniProtKB/Swiss-Prot
    O14846, Q4KMP9, Q6NT81, Q7L945, Q9BRG4
    Related
    ENSP00000354414.4, ENST00000361113.10
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:174382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:377402
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11597483..11619161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438385.1XP_047294341.1  zinc finger protein 627 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11725009..11747346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320152.1XP_054176127.1  zinc finger protein 627 isoform X1