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TTC21A tetratricopeptide repeat domain 21A [ Homo sapiens (human) ]

Gene ID: 199223, updated on 17-Jun-2019

Summary

Official Symbol
TTC21Aprovided by HGNC
Official Full Name
tetratricopeptide repeat domain 21Aprovided by HGNC
Primary source
HGNC:HGNC:30761
See related
Ensembl:ENSG00000168026 MIM:611430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STI2; SPGF37; IFT139A
Expression
Biased expression in testis (RPKM 39.0) and lung (RPKM 1.7) See more
Orthologs

Genomic context

See TTC21A in Genome Data Viewer
Location:
3p22.2
Exon count:
30
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (39107661..39139009)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39149152..39180394)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene RNA, U6 small nuclear 1227, pseudogene Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene uncharacterized LOC101928263 Neighboring gene microRNA 6822 Neighboring gene cysteine and serine rich nuclear protein 1 Neighboring gene uncharacterized LOC105377035

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70523, MGC156293, DKFZp686P18239

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetratricopeptide repeat protein 21A
Names
TPR domain containing STI2
TPR repeat protein 21A
stress-inducible protein 2
testicular tissue protein Li 212

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105513.2NP_001098983.2  tetratricopeptide repeat protein 21A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA843452, AK093313, AK098528, AK302465, DC403032
    Consensus CDS
    CCDS43068.2
    UniProtKB/Swiss-Prot
    Q8NDW8
    Related
    ENSP00000410882.1, ENST00000440121.1
    Conserved Domains (5) summary
    sd00006
    Location:684708
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:467550
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:11561217
    TPR_11; TPR repeat
    pfam13432
    Location:684747
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:851918
    TPR_19; Tetratricopeptide repeat
  2. NM_001366899.1NP_001353828.1  tetratricopeptide repeat protein 21A isoform 3

    Status: VALIDATED

    Source sequence(s)
    HM005525
    Conserved Domains (3) summary
    sd00006
    Location:733757
    TPR; TPR repeat [structural motif]
    cl26000
    Location:11031233
    YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
    cl26002
    Location:3221055
    TPR_11; TPR repeat
  3. NM_001366900.1NP_001353829.1  tetratricopeptide repeat protein 21A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092053, AC138124
  4. NM_145755.2NP_665698.2  tetratricopeptide repeat protein 21A isoform 2

    See identical proteins and their annotated locations for NP_665698.2

    Status: VALIDATED

    Source sequence(s)
    AA843452, AJ487015, AK093313, AK098528, DB094952, DC403032
    Consensus CDS
    CCDS46800.1
    UniProtKB/Swiss-Prot
    Q8NDW8
    Related
    ENSP00000398211.2, ENST00000431162.6
    Conserved Domains (5) summary
    sd00006
    Location:732756
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:518598
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:12041265
    TPR_11; TPR repeat
    pfam13432
    Location:732795
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:899966
    TPR_19; Tetratricopeptide repeat

RNA

  1. NR_159494.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092053, AC138124, BC129948
  2. NR_159495.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092053, AC138124
  3. NR_159496.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092053, AC138124

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    39107661..39139009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264925.5XP_005264982.1  tetratricopeptide repeat protein 21A isoform X7

    Conserved Domains (5) summary
    sd00006
    Location:684708
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:467550
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:11701231
    TPR_11; TPR repeat
    pfam13432
    Location:684747
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:851918
    TPR_19; Tetratricopeptide repeat
  2. XM_005264921.5XP_005264978.1  tetratricopeptide repeat protein 21A isoform X1

    Conserved Domains (5) summary
    sd00006
    Location:725749
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:12111272
    TPR_11; TPR repeat
    pfam13432
    Location:725788
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:892959
    TPR_19; Tetratricopeptide repeat
  3. XM_005264922.5XP_005264979.1  tetratricopeptide repeat protein 21A isoform X2

    Conserved Domains (5) summary
    sd00006
    Location:725749
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:12061267
    TPR_11; TPR repeat
    pfam13432
    Location:725788
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:892959
    TPR_19; Tetratricopeptide repeat
  4. XM_006713011.4XP_006713074.1  tetratricopeptide repeat protein 21A isoform X3

    Conserved Domains (5) summary
    sd00006
    Location:725749
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:12021263
    TPR_11; TPR repeat
    pfam13432
    Location:725788
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:892959
    TPR_19; Tetratricopeptide repeat
  5. XM_005264924.5XP_005264981.1  tetratricopeptide repeat protein 21A isoform X6

    Conserved Domains (4) summary
    sd00006
    Location:497522
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:11741235
    TPR_11; TPR repeat
    pfam14559
    Location:855922
    TPR_19; Tetratricopeptide repeat
  6. XM_005264926.5XP_005264983.1  tetratricopeptide repeat protein 21A isoform X8

    Conserved Domains (4) summary
    sd00006
    Location:497522
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:10931154
    TPR_11; TPR repeat
    pfam14559
    Location:774841
    TPR_19; Tetratricopeptide repeat
  7. XM_017005843.2XP_016861332.1  tetratricopeptide repeat protein 21A isoform X9

  8. XM_011533447.3XP_011531749.1  tetratricopeptide repeat protein 21A isoform X5

    Conserved Domains (5) summary
    sd00006
    Location:692716
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:475558
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:11781239
    TPR_11; TPR repeat
    pfam13432
    Location:692755
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:859926
    TPR_19; Tetratricopeptide repeat
  9. XM_024453382.1XP_024309150.1  tetratricopeptide repeat protein 21A isoform X11

    Conserved Domains (2) summary
    sd00006
    Location:725749
    TPR; TPR repeat [structural motif]
    cl26002
    Location:5775
    TPR_11; TPR repeat
  10. XM_011533449.2XP_011531751.1  tetratricopeptide repeat protein 21A isoform X12

    Conserved Domains (3) summary
    COG0457
    Location:28246
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:497522
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:508591
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
  11. XM_005264927.4XP_005264984.1  tetratricopeptide repeat protein 21A isoform X10

    Conserved Domains (5) summary
    sd00006
    Location:538562
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:321404
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:10241085
    TPR_11; TPR repeat
    pfam13432
    Location:538601
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:705772
    TPR_19; Tetratricopeptide repeat

RNA

  1. XR_001740049.2 RNA Sequence

  2. XR_427256.3 RNA Sequence

  3. XR_427257.3 RNA Sequence

  4. XR_001740050.2 RNA Sequence

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