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Ttc21a tetratricopeptide repeat domain 21A [ Mus musculus (house mouse) ]

Gene ID: 74052, updated on 26-Sep-2022

Summary

Official Symbol
Ttc21aprovided by MGI
Official Full Name
tetratricopeptide repeat domain 21Aprovided by MGI
Primary source
MGI:MGI:1921302
See related
Ensembl:ENSMUSG00000032514 AllianceGenome:MGI:1921302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thm2; 4921538N17Rik
Summary
Involved in flagellated sperm motility and spermatid development. Predicted to be part of intraciliary transport particle A. Is expressed in 4th ventricle; choroid plexus; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 28.9), lung adult (RPKM 4.7) and 1 other tissue See more
Orthologs
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Genomic context

See Ttc21a in Genome Data Viewer
Location:
9; 9 F4
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119766656..119798496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119937589..119969430)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2449 Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene cysteine-serine-rich nuclear protein 1 Neighboring gene predicted gene, 33800

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetratricopeptide repeat protein 21A
Names
TPR repeat protein 21A
tetratricopeptide repeat-containing hedgehog modulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028735.3NP_083011.2  tetratricopeptide repeat protein 21A

    See identical proteins and their annotated locations for NP_083011.2

    Status: VALIDATED

    Source sequence(s)
    AC124662, AK029952, BC133699
    Consensus CDS
    CCDS40805.1
    UniProtKB/Swiss-Prot
    Q8C0S4, Q9D5Q9
    Related
    ENSMUSP00000035100.6, ENSMUST00000035100.6
    Conserved Domains (4) summary
    TIGR02917
    Location:2091048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495522
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:11981259
    TPR_11; TPR repeat
    cl21457
    Location:50106
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119766656..119798496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512321.3XP_006512384.1  tetratricopeptide repeat protein 21A isoform X1

    Conserved Domains (2) summary
    TIGR02917
    Location:2091048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495522
    TPR; TPR repeat [structural motif]
  2. XM_036155346.1XP_036011239.1  tetratricopeptide repeat protein 21A isoform X2

    Related
    ENSMUST00000159128.8
    Conserved Domains (3) summary
    TIGR02917
    Location:2091048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495522
    TPR; TPR repeat [structural motif]
    cl21457
    Location:50106
    TIM; TIM-like beta/alpha barrel domains
  3. XM_036155347.1XP_036011240.1  tetratricopeptide repeat protein 21A isoform X3

    Conserved Domains (2) summary
    TIGR02917
    Location:55617
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:6491
    TPR; TPR repeat [structural motif]