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EIF4A2 eukaryotic translation initiation factor 4A2 [ Homo sapiens (human) ]

Gene ID: 1974, updated on 2-Mar-2021

Summary

Official Symbol
EIF4A2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4A2provided by HGNC
Primary source
HGNC:HGNC:3284
See related
Ensembl:ENSG00000156976 MIM:601102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II
Expression
Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues See more
Orthologs
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Genomic context

See EIF4A2 in Genome Data Viewer
Location:
3q27.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186783577..186789897)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186501366..186507686)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1105, pseudogene Neighboring gene G protein pathway suppressor 2 pseudogene 2 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene small nucleolar RNA, H/ACA box 63B Neighboring gene microRNA 1248 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene small nucleolar RNA, H/ACA box 63 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene replication factor C subunit 4 Neighboring gene long intergenic non-protein coding RNA 2043

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 4A2 (EIF4A2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Expression of HIV-1 Gag requires eIF4E, eIF4G, and eIF4A (eIF4F) binding to the viral 5'UTR PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 4A2 (EIF4A2) at amino acid residues 375-376 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
helicase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of RNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic initiation factor 4A-II
Names
ATP-dependent RNA helicase eIF4A-2
NP_001958.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001967.4NP_001958.2  eukaryotic initiation factor 4A-II

    See identical proteins and their annotated locations for NP_001958.2

    Status: VALIDATED

    Source sequence(s)
    AL556981, BC013708, BC015842, D30655
    Consensus CDS
    CCDS3282.1
    UniProtKB/Swiss-Prot
    Q14240
    Related
    ENSP00000326381.5, ENST00000323963.10
    Conserved Domains (1) summary
    PTZ00424
    Location:21407
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186783577..186789897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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