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EIF4A2 eukaryotic translation initiation factor 4A2 [ Homo sapiens (human) ]

Gene ID: 1974, updated on 7-Jan-2024

Summary

Official Symbol
EIF4A2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4A2provided by HGNC
Primary source
HGNC:HGNC:3284
See related
Ensembl:ENSG00000156976 MIM:601102; AllianceGenome:HGNC:3284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX2B; EIF4A; EIF4F; BM-010; NEDHSS; eIF4A-II; eIF-4A-II
Summary
Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues See more
Orthologs
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Genomic context

See EIF4A2 in Genome Data Viewer
Location:
3q27.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (186783577..186789897)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (189605607..189611927)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186501366..186507686)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1105, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186493608-186494442 Neighboring gene G protein pathway suppressor 2 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:186495182-186495383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20943 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene small nucleolar RNA, H/ACA box 63B Neighboring gene microRNA 1248 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene small nucleolar RNA, H/ACA box 63 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene replication factor C subunit 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186523827-186524438 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186524439-186525050 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:186529516-186529618 Neighboring gene long intergenic non-protein coding RNA 2043

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures
MedGen: C5830654 OMIM: 620455 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 4A2 (EIF4A2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Expression of HIV-1 Gag requires eIF4E, eIF4G, and eIF4A (eIF4F) binding to the viral 5'UTR PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 4A2 (EIF4A2) at amino acid residues 375-376 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic initiation factor 4A-II
Names
ATP-dependent RNA helicase eIF4A-2
NP_001958.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001967.4NP_001958.2  eukaryotic initiation factor 4A-II

    See identical proteins and their annotated locations for NP_001958.2

    Status: VALIDATED

    Source sequence(s)
    AL556981, BC013708, BC015842, D30655
    Consensus CDS
    CCDS3282.1
    UniProtKB/Swiss-Prot
    D3DNU9, Q14240, Q53XJ6, Q96B90, Q96EA8
    UniProtKB/TrEMBL
    A8K088, A8K7F6
    Related
    ENSP00000326381.5, ENST00000323963.10
    Conserved Domains (1) summary
    PTZ00424
    Location:21407
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    186783577..186789897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    189605607..189611927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)