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Eif4a2 eukaryotic translation initiation factor 4A2 [ Mus musculus (house mouse) ]

Gene ID: 13682, updated on 2-Nov-2024

Summary

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Official Symbol
Eif4a2provided by MGI
Official Full Name
eukaryotic translation initiation factor 4A2provided by MGI
Primary source
MGI:MGI:106906
See related
Ensembl:ENSMUSG00000022884 AllianceGenome:MGI:106906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4; Ddx2b; BM-010; eIF4A-II; eIF-4A-II; 4833432N07Rik
Summary
Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Is expressed in brain; early conceptus; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 124.6), bladder adult (RPKM 120.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Eif4a2 in Genome Data Viewer
Location:
16 B1; 16 13.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22924846..22932882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23107468..23114132)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40426 Neighboring gene kininogen 1 Neighboring gene STARR-seq mESC enhancer starr_40430 Neighboring gene STARR-seq mESC enhancer starr_40432 Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene predicted gene, 24201 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene predicted gene, 26447 Neighboring gene predicted gene, 24616 Neighboring gene STARR-positive B cell enhancer ABC_E8623 Neighboring gene replication factor C (activator 1) 4 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23165651-23165889 Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene predicted pseudogene 6630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Balakin AG, et al. Cell, 1996 Sep 6. PMID 8797828
  2. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. Sudo K, et al. Cytogenet Cell Genet, 1995. PMID 8521730
  3. Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status. Williams-Hill DM, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015395
  4. Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation. Galicia-Vázquez G, et al. PLoS One, 2014. PMID 24466343, Free PMC Article
  5. Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos. De Sousa PA, et al. Biol Reprod, 1998 Oct. PMID 9746750

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4833432N07

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RNA-dependent RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of RNA-dependent RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic initiation factor 4A-II
Names
ATP-dependent RNA helicase eIF4A-2
NP_001116509.1
NP_001116510.1
NP_001334108.1
NP_038534.2
XP_006521847.1
XP_006521848.1
XP_030104824.1
XP_030104825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123037.2 → NP_001116509.1  eukaryotic initiation factor 4A-II isoform b

    See identical proteins and their annotated locations for NP_001116509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' coding region, which leads to a frameshift and use of an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC154540, AK076509, BC094422, BY286182, CF723811
    Consensus CDS
    CCDS49806.1
    UniProtKB/TrEMBL
    E9Q561
    Related
    ENSMUSP00000127030.2, ENSMUST00000168891.8
    Conserved Domains (1) summary
    PTZ00424
    Location:18 → 312
    PTZ00424; helicase 45; Provisional

  2. NM_001123038.2 → NP_001116510.1  eukaryotic initiation factor 4A-II isoform c

    See identical proteins and their annotated locations for NP_001116510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3'-terminal exon, which leads to a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC154540, AK076509, BC094422, BG091741, BY286182, CF723811, CF898280, CK623185
    Consensus CDS
    CCDS49805.1
    UniProtKB/TrEMBL
    A0A338P6X5, Q8BTU6
    Related
    ENSMUSP00000090876.5, ENSMUST00000077605.12
    Conserved Domains (1) summary
    PTZ00424
    Location:21 → 360
    PTZ00424; helicase 45; Provisional

  3. NM_001347179.2 → NP_001334108.1  eukaryotic initiation factor 4A-II isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AC154540
    Consensus CDS
    CCDS84218.1
    UniProtKB/TrEMBL
    Q4FZL1
    Conserved Domains (1) summary
    PTZ00424
    Location:9 → 408
    PTZ00424; helicase 45; Provisional

  4. NM_013506.3 → NP_038534.2  eukaryotic initiation factor 4A-II isoform a

    See identical proteins and their annotated locations for NP_038534.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC154540, AK076509, BC094422, BY286182, CF723811
    Consensus CDS
    CCDS28074.1
    UniProtKB/Swiss-Prot
    P10630, Q61513, Q61514
    UniProtKB/TrEMBL
    Q4FZL1, Q52KC1
    Related
    ENSMUSP00000023599.7, ENSMUST00000023599.13
    Conserved Domains (1) summary
    PTZ00424
    Location:21 → 407
    PTZ00424; helicase 45; Provisional

RNA

  1. NR_110335.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154540, AK076509, AK132969, BC094422, BY286182, CF723811

  2. NR_152586.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154540

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22924846..22932882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521784.4 → XP_006521847.1  eukaryotic initiation factor 4A-II isoform X1

    See identical proteins and their annotated locations for XP_006521847.1

    UniProtKB/TrEMBL
    A0A338P6X5
    Related
    ENSMUSP00000156170.2, ENSMUST00000232287.2
    Conserved Domains (1) summary
    PTZ00424
    Location:9 → 361
    PTZ00424; helicase 45; Provisional

  2. XM_006521785.3 → XP_006521848.1  eukaryotic initiation factor 4A-II isoform X2

    See identical proteins and their annotated locations for XP_006521848.1

    UniProtKB/TrEMBL
    E9Q561
    Conserved Domains (1) summary
    PTZ00424
    Location:18 → 312
    PTZ00424; helicase 45; Provisional

  3. XM_030248964.1 → XP_030104824.1  eukaryotic initiation factor 4A-II isoform X3

    Conserved Domains (1) summary
    PTZ00424
    Location:18 → 265
    PTZ00424; helicase 45; Provisional

  4. XM_030248965.1 → XP_030104825.1  eukaryotic initiation factor 4A-II isoform X3

    Conserved Domains (1) summary
    PTZ00424
    Location:18 → 265
    PTZ00424; helicase 45; Provisional

RNA

  1. XR_384524.4 RNA Sequence

  2. XR_384525.4 RNA Sequence

  3. XR_003951756.1 RNA Sequence

  4. XR_003951757.1 RNA Sequence

    Related
    ENSMUST00000147117.8

  5. XR_003951758.1 RNA Sequence

  6. XR_003951759.1 RNA Sequence

    Related
    ENSMUST00000131871.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10630.2 GenPept UniProtKB/Swiss-Prot:P10630

Gene LinkOut

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