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Rest RE1-silencing transcription factor [ Mus musculus (house mouse) ]

Gene ID: 19712, updated on 17-Jan-2023

Summary

Official Symbol
Restprovided by MGI
Official Full Name
RE1-silencing transcription factorprovided by MGI
Primary source
MGI:MGI:104897
See related
Ensembl:ENSMUSG00000029249 AllianceGenome:MGI:104897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRSF; REST4; 2610008J04Rik
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including auditory receptor cell stereocilium organization; regulation of gene expression; and regulation of neuron differentiation. Acts upstream of or within hematopoietic progenitor cell differentiation; negative regulation of neurogenesis; and regulation of gene expression. Located in cytosol and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.4), limb E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rest in Genome Data Viewer
Location:
5; 5 C3.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77413273..77434279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77265494..77286432)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 2 Neighboring gene predicted gene, 19060 Neighboring gene microRNA 5098 Neighboring gene nitric oxide associated 1 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene insulin-like growth factor binding protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150099

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amniotic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dense core granule biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mesenchymal stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RE1-silencing transcription factor
Names
neural-restrictive silencer factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011263.2NP_035393.2  RE1-silencing transcription factor

    See identical proteins and their annotated locations for NP_035393.2

    Status: VALIDATED

    Source sequence(s)
    AI121875, AK004945, BC127065, BE132774
    Consensus CDS
    CCDS19372.1
    UniProtKB/Swiss-Prot
    Q8VIG1, Q9CW43
    Related
    ENSMUSP00000079231.6, ENSMUST00000080359.12
    Conserved Domains (4) summary
    PRK12323
    Location:607776
    PRK12323; DNA polymerase III subunit gamma/tau
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313338
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:299323
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    77413273..77434279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164926.1XP_036020819.1  RE1-silencing transcription factor isoform X2

    UniProtKB/TrEMBL
    F8V330
    Conserved Domains (3) summary
    sd00017
    Location:245265
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:285310
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:299322
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_006534842.5XP_006534905.1  RE1-silencing transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006534905.1

    UniProtKB/Swiss-Prot
    Q8VIG1, Q9CW43
    Related
    ENSMUSP00000109076.2, ENSMUST00000113449.2
    Conserved Domains (4) summary
    PRK12323
    Location:607776
    PRK12323; DNA polymerase III subunit gamma/tau
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313338
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:299323
    zf-H2C2_5; C2H2-type zinc-finger domain