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Rdx radixin [ Mus musculus (house mouse) ]

Gene ID: 19684, updated on 5-Mar-2024

Summary

Official Symbol
Rdxprovided by MGI
Official Full Name
radixinprovided by MGI
Primary source
MGI:MGI:97887
See related
Ensembl:ENSMUSG00000032050 AllianceGenome:MGI:97887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein domain specific binding activity. Involved in cellular response to thyroid hormone stimulus; establishment of protein localization; and positive regulation of G1/S transition of mitotic cell cycle. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; microvillus; and ruffle. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.7), placenta adult (RPKM 29.6) and 23 other tissues See more
Orthologs
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Genomic context

See Rdx in Genome Data Viewer
Location:
9 A5.3; 9 28.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51958450..52000038)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (52047150..52088738)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene STARR-seq mESC enhancer starr_24133 Neighboring gene ferredoxin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene zinc finger CCCH type containing 12C Neighboring gene microRNA 6244 Neighboring gene STARR-positive B cell enhancer ABC_E3829 Neighboring gene predicted gene, 25562

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to thyroid hormone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of organelle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of organelle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell tip ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104616.1NP_001098086.1  radixin isoform a

    See identical proteins and their annotated locations for NP_001098086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AK162204, BE994963, DV662898
    Consensus CDS
    CCDS40634.1
    UniProtKB/Swiss-Prot
    P26043, Q3TS85, Q9QW27
    UniProtKB/TrEMBL
    Q3UJJ8
    Related
    ENSMUSP00000128249.2, ENSMUST00000163153.9
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347583
    ERM; Ezrin/radixin/moesin family
  2. NM_001104617.1NP_001098087.1  radixin isoform b

    See identical proteins and their annotated locations for NP_001098087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK016711, BC053417, BY739389
    Consensus CDS
    CCDS52793.1
    UniProtKB/TrEMBL
    Q7TSG6, Q8C2N4
    Related
    ENSMUSP00000055303.10, ENSMUST00000061352.11
    Conserved Domains (4) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:91206
    FERM_M; FERM central domain
    pfam09379
    Location:971
    FERM_N; FERM N-terminal domain
  3. NM_009041.3NP_033067.2  radixin isoform a

    See identical proteins and their annotated locations for NP_033067.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK162204, AK168449, BE994963, BY739389
    Consensus CDS
    CCDS40634.1
    UniProtKB/Swiss-Prot
    P26043, Q3TS85, Q9QW27
    UniProtKB/TrEMBL
    Q3UJJ8
    Related
    ENSMUSP00000000590.9, ENSMUST00000000590.16
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347583
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    51958450..52000038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)