Format

Send to:

Choose Destination

EIF2S1 eukaryotic translation initiation factor 2 subunit alpha [ Homo sapiens (human) ]

Gene ID: 1965, updated on 3-May-2020

Summary

Official Symbol
EIF2S1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 2 subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:3265
See related
Ensembl:ENSG00000134001 MIM:603907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
Summary
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Annotation information
Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018]
Expression
Ubiquitous expression in testis (RPKM 19.0), esophagus (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See EIF2S1 in Genome Data Viewer
Location:
14q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (67360328..67386516)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (67827034..67853233)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene membrane palmitoylated protein 5 Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene GATA motif-containing MPRA enhancer 49

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes with eIF-2alpha in human cells PubMed
Tat tat Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP PubMed
tat Neurons exposed to HIV-1 Tat induces calcium loss from the endoplasmic reticulum via ryanodine receptor (RyR) and increases the phosphorylated levels of PERK, eIF2a, and XBP1 PubMed
tat HIV-1 Tat competes with eukaryotic initiation factor 2, a well characterized substrate of PKR, for phosphorylation by activated PKR PubMed
tat Eukaryotic translation initiation factor 2 (eIF2) recognizes and binds the TAR secondary structure in HIV-1 RNA, suggesting a role in Tat transactivation of the viral LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
PERK-mediated unfolded protein response NAS
Non-traceable Author Statement
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type B pancreatic cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to manganese-induced endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
glial limiting end-foot IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
polysome TAS
Traceable Author Statement
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
translation initiation ternary complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 1
Names
eIF-2-alpha
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004094.5NP_004085.1  eukaryotic translation initiation factor 2 subunit 1

    See identical proteins and their annotated locations for NP_004085.1

    Status: VALIDATED

    Source sequence(s)
    AL139785, BC002513
    Consensus CDS
    CCDS9781.1
    UniProtKB/Swiss-Prot
    P05198
    UniProtKB/TrEMBL
    Q53XC0
    Related
    ENSP00000256383.4, ENST00000256383.10
    Conserved Domains (1) summary
    PTZ00248
    Location:4315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    67360328..67386516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center