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Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 13665, updated on 28-Dec-2022

Summary

Official Symbol
Eif2s1provided by MGI
Official Full Name
eukaryotic translation initiation factor 2, subunit 1 alphaprovided by MGI
Primary source
MGI:MGI:95299
See related
Ensembl:ENSMUSG00000021116 AllianceGenome:MGI:95299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik
Summary
Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 24.6), liver E14 (RPKM 23.2) and 26 other tissues See more
Orthologs
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Genomic context

See Eif2s1 in Genome Data Viewer
Location:
12; 12 C3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78908846..78933784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78862072..78887010)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene protein associated with LIN7 1, MAGUK family member Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene predicted gene, 46359 Neighboring gene predicted gene, 46360

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translational initiation in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of translational initiation in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
located_in glial limiting end-foot ISO
Inferred from Sequence Orthology
more info
 
part_of multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of translation initiation ternary complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 1
Names
eIF-2-alpha
eIF-2A
eIF-2alpha
eukaryotic translation initiation factor 2 subunit alpha
eukaryotic translation initiation factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026114.3NP_080390.1  eukaryotic translation initiation factor 2 subunit 1

    See identical proteins and their annotated locations for NP_080390.1

    Status: PROVISIONAL

    Source sequence(s)
    AK143499
    Consensus CDS
    CCDS26003.1
    UniProtKB/Swiss-Prot
    Q3TIQ0, Q6ZWX6
    UniProtKB/TrEMBL
    A0A6P5QTR3, A0A8C6H863
    Related
    ENSMUSP00000071214.8, ENSMUST00000071230.8
    Conserved Domains (1) summary
    PTZ00248
    Location:4315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    78908846..78933784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)