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MEGF9 multiple EGF like domains 9 [ Homo sapiens (human) ]

Gene ID: 1955, updated on 4-Jun-2020

Summary

Official Symbol
MEGF9provided by HGNC
Official Full Name
multiple EGF like domains 9provided by HGNC
Primary source
HGNC:HGNC:3234
See related
Ensembl:ENSG00000106780 MIM:604268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGFL5
Expression
Ubiquitous expression in thyroid (RPKM 22.6), brain (RPKM 20.0) and 24 other tissues See more
Orthologs

Genomic context

See MEGF9 in Genome Data Viewer
Location:
9q33.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (120600811..120714470, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123363196..123476765, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376253 Neighboring gene CDK5 regulatory subunit associated protein 2 Neighboring gene NFE2L2 motif-containing MPRA enhancer 171 Neighboring gene adenosylhomocysteinase pseudogene 2 Neighboring gene F-box and WD repeat domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multiple epidermal growth factor-like domains protein 9
Names
EGF-like-domain, multiple 5
epidermal growth factor-like protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080497.3NP_001073966.2  multiple epidermal growth factor-like domains protein 9 precursor

    See identical proteins and their annotated locations for NP_001073966.2

    Status: VALIDATED

    Source sequence(s)
    AB011542, AJ420444, AK295380, AL138836, BC016989, CK300579
    Consensus CDS
    CCDS48010.2
    UniProtKB/Swiss-Prot
    Q9H1U4
    Related
    ENSP00000363040.3, ENST00000373930.4
    Conserved Domains (2) summary
    cd00055
    Location:204252
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:254301
    Laminin_EGF; Laminin EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    120600811..120714470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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