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Ran RAN, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19384, updated on 29-Oct-2022

Summary

Official Symbol
Ranprovided by MGI
Official Full Name
RAN, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1333112
See related
Ensembl:ENSMUSG00000029430 AllianceGenome:MGI:1333112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within actin cytoskeleton organization; protein import into nucleus; and protein-containing complex localization. Located in cytoplasm and nuclear envelope. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 161.6), liver E14 (RPKM 152.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ran in Genome Data Viewer
Location:
5; 5 G1.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129097220..129101386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129020156..129024322)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIMS binding protein 2 Neighboring gene predicted gene, 34057 Neighboring gene syntaxin 2 Neighboring gene predicted gene, 52830 Neighboring gene adhesion G protein-coupled receptor D1 Neighboring gene predicted gene, 46923

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Ran gene: The Ran gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 470 organisms have orthologs with human gene Ran
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA import into nucleus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA nuclear export complex ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in manchette ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GTP-binding nuclear protein Ran
Names
GTPase Ran
ras-like protein TC4
ras-related nuclear protein
NP_033417.1
XP_006504343.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009391.3NP_033417.1  GTP-binding nuclear protein Ran

    See identical proteins and their annotated locations for NP_033417.1

    Status: VALIDATED

    Source sequence(s)
    AC110566, AK002436, AK075900
    Consensus CDS
    CCDS19693.1
    UniProtKB/Swiss-Prot
    P62827
    UniProtKB/TrEMBL
    A0A6P5PQK7, A0A8C6GHT7
    Related
    ENSMUSP00000031383.8, ENSMUST00000031383.14
    Conserved Domains (1) summary
    smart00176
    Location:16215
    RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129097220..129101386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504280.5XP_006504343.1  GTP-binding nuclear protein Ran isoform X1

    See identical proteins and their annotated locations for XP_006504343.1

    UniProtKB/Swiss-Prot
    P62827
    UniProtKB/TrEMBL
    A0A6P5PQK7, A0A8C6GHT7
    Related
    ENSMUSP00000106975.2, ENSMUST00000111343.2
    Conserved Domains (1) summary
    smart00176
    Location:16215
    RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases