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RAN RAN, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5901, updated on 5-Jan-2022

Summary

Official Symbol
RANprovided by HGNC
Official Full Name
RAN, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9846
See related
Ensembl:ENSG00000132341 MIM:601179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TC4; Gsp1; ARA24
Summary
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues See more
Orthologs
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Genomic context

See RAN in Genome Data Viewer
Location:
12q24.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (130871879..130877678)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131356611..131362223)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 967 Neighboring gene syntaxin 2 Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4789 Neighboring gene adhesion G protein-coupled receptor D1 Neighboring gene ADGRD1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Ran terminates the nuclear import of the Matrix protein of HIV-1 Gag by directly binding to karyopherin beta and disassembling the import complex PubMed
Rev rev the GTP bound form of Ran (RanGTP) binds to a preformed Rev-CRM1 (exportin 1) complex to mediate nuclear export of HIV-1 mRNA PubMed
rev A dimeric CRM1-RanGTP complex binds a Rev-RRE complex to export the Rev-RRE complex from the nuclear to the cytoplasm in cells PubMed
rev HIV-1 Rev interacting protein, RAN, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
rev Rev-Rev interactions (multimerization) are enhanced by RanGTP PubMed
rev binding of the GTP bound form of Ran (RanGTP) to a preformed Rev-CRM1 complex is linked to an interaction of RanGTP with the nuclear export signal (NES) of Rev (amino acids 75-83) PubMed
Tat tat Interaction of HIV-1 Tat with RAN in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
capsid gag RanGTP inhibits the ability of TNPO3 to stimulate the uncoating of HIV-1 CA cores PubMed
integrase gag-pol The binding between HIV-1 IN and TNPO3 is inhibited by RanGTP in a dose-dependent manner, leading to a TNPO3-RanGTP complex formation PubMed
matrix gag Ran terminates the nuclear import of HIV-1 Matrix by directly binding to karyopherin beta and disassembling the import complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the RAN gene: The RAN gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 422 organisms have orthologs with human gene RAN
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables chromatin binding TAS
Traceable Author Statement
more info
PubMed 
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables importin-alpha family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nuclear export signal receptor activity IC
Inferred by Curator
more info
PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in GTP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mineralocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pre-miRNA export from nucleus IC
Inferred by Curator
more info
PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
involved_in viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
NOT located_in Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA nuclear export complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in manchette IEA
Inferred from Electronic Annotation
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm flagellum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP-binding nuclear protein Ran
Names
GTPase Ran
RanGTPase
androgen receptor-associated protein 24
guanosine triphosphatase Ran
member RAS oncogene family
ras-like protein TC4
ras-related nuclear protein
NP_001287725.1
NP_001287726.1
NP_006316.1
XP_016875261.1
XP_016875262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300796.2NP_001287725.1  GTP-binding nuclear protein Ran isoform 2

    See identical proteins and their annotated locations for NP_001287725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC073912, AF054183, AK316193
    Consensus CDS
    CCDS73546.1
    UniProtKB/Swiss-Prot
    P62826
    UniProtKB/TrEMBL
    B4DV51
    Related
    ENSP00000441210.1, ENST00000541630.5
    Conserved Domains (1) summary
    smart00176
    Location:1127
    RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
  2. NM_001300797.2NP_001287726.1  GTP-binding nuclear protein Ran isoform 2

    See identical proteins and their annotated locations for NP_001287726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC073912, AK300934, HY139187
    Consensus CDS
    CCDS73546.1
    UniProtKB/Swiss-Prot
    P62826
    UniProtKB/TrEMBL
    B4DV51
    Conserved Domains (1) summary
    smart00176
    Location:1127
    RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
  3. NM_006325.5NP_006316.1  GTP-binding nuclear protein Ran isoform 1

    See identical proteins and their annotated locations for NP_006316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073912, AF054183, BC000852
    Consensus CDS
    CCDS9271.1
    UniProtKB/Swiss-Prot
    P62826
    Related
    ENSP00000446215.1, ENST00000543796.6
    Conserved Domains (1) summary
    smart00176
    Location:16215
    RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    130871879..130877678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019772.1XP_016875261.1  GTP-binding nuclear protein Ran isoform X1

    Related
    ENSP00000444042.1, ENST00000535090.5
  2. XM_017019773.1XP_016875262.1  GTP-binding nuclear protein Ran isoform X2

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