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EEF2 eukaryotic translation elongation factor 2 [ Homo sapiens (human) ]

Gene ID: 1938, updated on 3-Jun-2018
Official Symbol
EEF2provided by HGNC
Official Full Name
eukaryotic translation elongation factor 2provided by HGNC
Primary source
HGNC:HGNC:3214
See related
Ensembl:ENSG00000167658 MIM:130610; Vega:OTTHUMG00000181790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF2; EF-2; EEF-2; SCA26
Summary
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues See more
Orthologs
See EEF2 in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (3976056..3985463, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3976054..3985477, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nicotinamide riboside kinase 2 Neighboring gene death associated protein kinase 3 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene zinc finger and BTB domain containing 7A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EEF2 PubMed
SiRNA-mediated depletion of EEF2 protein inhibits HIV-1 replication and infectivity in human cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Treatment of cells with cyclosporine A blocks the interaction of HIV-1 Gag with eEF2, indicating that cyclophilin A (CypA) stabilizes the Gag-eEF2 association PubMed
gag The CA N-terminal domain of HIV-1 Gag mediates eEF2 binding in cells PubMed
gag Overexpression of G3BP1 inhibits the interaction between HIV-1 Gag and eEF2 in cells, suggesting that G3BP1 competes with eEF2 binding to Gag PubMed
gag SiRNA-mediated depletion of eEF2 protein modulates HIV-1 production by measurement of HIV-Gag in virions PubMed
gag HIV-1 Gag interacts with eEF2 to block stress granule (SG) assembly and siRNA-mediated depletion of eEF2 fails to inhibit SG assembly PubMed
Vpr vpr Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 2 (EEF2) at amino acid residues 395-396 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
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  • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
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  • Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem (from REACTOME)
    Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
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  • Infectious disease, organism-specific biosystem (from REACTOME)
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  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
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  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
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  • Peptide chain elongation, organism-specific biosystem (from REACTOME)
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  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
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  • Synthesis of diphthamide-EEF2, organism-specific biosystem (from REACTOME)
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  • Translation, organism-specific biosystem (from REACTOME)
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    mTOR signaling pathway, organism-specific biosystem
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5S rRNA binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 
glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to folic acid IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational elongation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
polysomal ribosome IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
elongation factor 2
Names
polypeptidyl-tRNA translocase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042274.1 RefSeqGene

    Range
    5001..14408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001961.3NP_001952.1  elongation factor 2

    See identical proteins and their annotated locations for NP_001952.1

    Status: REVIEWED

    Source sequence(s)
    AU118535, AY942181, Z11692
    Consensus CDS
    CCDS12117.1
    UniProtKB/Swiss-Prot
    P13639
    Related
    ENSP00000307940.5, OTTHUMP00000267463, ENST00000309311.6, OTTHUMT00000457615
    Conserved Domains (1) summary
    PTZ00416
    Location:1858
    PTZ00416; elongation factor 2; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    3976056..3985463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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