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EEF2 eukaryotic translation elongation factor 2 [ Homo sapiens (human) ]

Gene ID: 1938, updated on 5-Sep-2021

Summary

Official Symbol
EEF2provided by HGNC
Official Full Name
eukaryotic translation elongation factor 2provided by HGNC
Primary source
HGNC:HGNC:3214
See related
Ensembl:ENSG00000167658 MIM:130610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF2; EF-2; EEF-2; SCA26
Summary
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues See more
Orthologs
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Genomic context

See EEF2 in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3976056..3985463, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3976054..3985461, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nicotinamide riboside kinase 2 Neighboring gene death associated protein kinase 3 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene zinc finger and BTB domain containing 7A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EEF2 PubMed
SiRNA-mediated depletion of EEF2 protein inhibits HIV-1 replication and infectivity in human cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Treatment of cells with cyclosporine A blocks the interaction of HIV-1 Gag with eEF2, indicating that cyclophilin A (CypA) stabilizes the Gag-eEF2 association PubMed
gag The CA N-terminal domain of HIV-1 Gag mediates eEF2 binding in cells PubMed
gag Overexpression of G3BP1 inhibits the interaction between HIV-1 Gag and eEF2 in cells, suggesting that G3BP1 competes with eEF2 binding to Gag PubMed
gag SiRNA-mediated depletion of eEF2 protein modulates HIV-1 production by measurement of HIV-Gag in virions PubMed
gag HIV-1 Gag interacts with eEF2 to block stress granule (SG) assembly and siRNA-mediated depletion of eEF2 fails to inhibit SG assembly PubMed
Vpr vpr Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 2 (EEF2) at amino acid residues 395-396 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5S rRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding HDA PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding HDA PubMed 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to folic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in polysomal ribosome IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongation factor 2
Names
epididymis secretory sperm binding protein
polypeptidyl-tRNA translocase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042274.1 RefSeqGene

    Range
    5001..14408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001961.4NP_001952.1  elongation factor 2

    See identical proteins and their annotated locations for NP_001952.1

    Status: REVIEWED

    Source sequence(s)
    AU118535, AY942181, Z11692
    Consensus CDS
    CCDS12117.1
    UniProtKB/Swiss-Prot
    P13639
    Related
    ENSP00000307940.5, ENST00000309311.7
    Conserved Domains (1) summary
    PTZ00416
    Location:1858
    PTZ00416; elongation factor 2; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3976056..3985463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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