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Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 13629, updated on 5-Feb-2023

Summary

Official Symbol
Eef2provided by MGI
Official Full Name
eukaryotic translation elongation factor 2provided by MGI
Primary source
MGI:MGI:95288
See related
Ensembl:ENSMUSG00000034994 AllianceGenome:MGI:95288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ef-2
Summary
Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm. Part of polysome. Is active in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
Orthologs
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Genomic context

See Eef2 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81012465..81018343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81176631..81182509)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC98463

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in polysomal ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007907.2NP_031933.1  elongation factor 2

    See identical proteins and their annotated locations for NP_031933.1

    Status: VALIDATED

    Source sequence(s)
    AK168794, CJ170931, CJ316208
    Consensus CDS
    CCDS35993.1
    UniProtKB/Swiss-Prot
    P58252, Q544E4
    UniProtKB/TrEMBL
    A0A8C6N1K7
    Related
    ENSMUSP00000046101.10, ENSMUST00000047864.11
    Conserved Domains (6) summary
    cd01885
    Location:20233
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:574746
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:742821
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1858
    PTZ00416; elongation factor 2; Provisional
    cd03700
    Location:394488
    EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
    cd16261
    Location:503574
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81012465..81018343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)