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Pxn paxillin [ Mus musculus (house mouse) ]

Gene ID: 19303, updated on 16-Aug-2021

Summary

Official Symbol
Pxnprovided by MGI
Official Full Name
paxillinprovided by MGI
Primary source
MGI:MGI:108295
See related
Ensembl:ENSMUSG00000029528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; Pax; AW108311; AW123232
Expression
Ubiquitous expression in lung adult (RPKM 49.8), colon adult (RPKM 41.3) and 28 other tissues See more
Orthologs
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Genomic context

See Pxn in Genome Data Viewer
Location:
5 F; 5 56.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115630153..115694046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115491970..115555987)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115956711..116005995)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene predicted gene, 24265 Neighboring gene predicted gene, 24407 Neighboring gene 40S ribosomal protein S5 pseudogene Neighboring gene predicted gene 13840 Neighboring gene ribosomal protein, large, P0 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 7029

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH4 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neuropilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuropilin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within movement of cell or subcellular component IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011223.3NP_035353.1  paxillin isoform alpha

    See identical proteins and their annotated locations for NP_035353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (alpha) lacks an alternate in-frame exon in the 5' coding region, compared to variant beta. It encodes isoform alpha, which lacks an internal segment and is shorter, compared to isoform beta.
    Source sequence(s)
    AK149933, AW123232, BY198095
    Consensus CDS
    CCDS19593.1
    UniProtKB/Swiss-Prot
    Q8VI36
    Related
    ENSMUSP00000069624.9, ENSMUST00000067268.15
    Conserved Domains (5) summary
    cd09407
    Location:383434
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09409
    Location:442494
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09411
    Location:501552
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:324376
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  2. NM_133915.3NP_598676.2  paxillin isoform beta

    See identical proteins and their annotated locations for NP_598676.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (beta) represents the longer transcript and encodes the longer isoform (beta).
    Source sequence(s)
    AC159539, AK149933, AW123232, BY198095
    Consensus CDS
    CCDS39229.1
    UniProtKB/Swiss-Prot
    Q8VI36
    UniProtKB/TrEMBL
    F8VQ28
    Related
    ENSMUSP00000083709.4, ENSMUST00000086523.7
    Conserved Domains (5) summary
    cd09338
    Location:476528
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:417468
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:535586
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:358410
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54253
    Paxillin; Paxillin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115630153..115694046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254218.2XP_030110078.1  paxillin isoform X7

    Related
    ENSMUSP00000144459.2, ENSMUST00000202564.2
    Conserved Domains (5) summary
    cd09338
    Location:343395
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09411
    Location:402453
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:225277
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    cl02475
    Location:284335
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam03535
    Location:1120
    Paxillin; Paxillin family
  2. XM_006530202.3XP_006530265.1  paxillin isoform X1

    Related
    ENSMUSP00000148843.3, ENSMUST00000212819.3
    Conserved Domains (5) summary
    cd09338
    Location:9731025
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:914965
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:10321083
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:855907
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  3. XM_036164917.1XP_036020810.1  paxillin isoform X2

    Conserved Domains (5) summary
    cd09338
    Location:842894
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:783834
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:901952
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:724776
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  4. XM_036164918.1XP_036020811.1  paxillin isoform X4

    Conserved Domains (5) summary
    cd09338
    Location:753805
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:694745
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:812863
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:635687
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  5. XM_006530207.5XP_006530270.1  paxillin isoform X5

    Conserved Domains (1) summary
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  6. XM_036164919.1XP_036020812.1  paxillin isoform X6

    Conserved Domains (1) summary
    pfam03535
    Location:54253
    Paxillin; Paxillin family
  7. XM_006530205.4XP_006530268.1  paxillin isoform X3

    See identical proteins and their annotated locations for XP_006530268.1

    Conserved Domains (5) summary
    cd09338
    Location:840892
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:781832
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:899950
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:722774
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:1120
    Paxillin; Paxillin family
  8. XM_006530204.4XP_006530267.1  paxillin isoform X3

    See identical proteins and their annotated locations for XP_006530267.1

    Conserved Domains (5) summary
    cd09338
    Location:840892
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:781832
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:899950
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:722774
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:1120
    Paxillin; Paxillin family

RNA

  1. XR_004942462.1 RNA Sequence

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