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PXN paxillin [ Homo sapiens (human) ]

Gene ID: 5829, updated on 18-Jan-2026
Official Symbol
PXNprovided by HGNC
Official Full Name
paxillinprovided by HGNC
Primary source
HGNC:HGNC:9718
See related
Ensembl:ENSG00000089159 MIM:602505; AllianceGenome:HGNC:9718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in placenta (RPKM 24.8), fat (RPKM 20.4) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PXN in Genome Data Viewer
Location:
12q24.23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120210447..120265730, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120197626..120252894, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120648250..120703533, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7132 Neighboring gene microRNA 4498 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120622010-120623209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120635999-120636498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120636618-120637559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7134 Neighboring gene Sharpr-MPRA regulatory region 12439 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120653807-120654533 Neighboring gene uncharacterized LOC124903034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120662858-120663539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120664223-120664903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4944 Neighboring gene hESC enhancers GRCh37_chr12:120667255-120667814 and GRCh37_chr12:120667815-120668374 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120668816-120670015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120670055-120670614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120671735-120672294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120676424-120677054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120682649-120683475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7137 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120697989-120698555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120717966-120718466 Neighboring gene hESC enhancers GRCh37_chr12:120727716-120728708 and GRCh37_chr12:120728709-120729700 Neighboring gene NME2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 2 Neighboring gene sirtuin 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients. Zhao CJ, et al. Med Sci Monit, 2015 Jul 10. PMID 26159303, Free PMC Article
  2. Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein. Bohl J, et al. Virology, 2000 May 25. PMID 10814581
  3. Role of paxillin in colorectal carcinoma and its relationship to clinicopathological features. Yin H, et al. Chin Med J (Engl), 2014. PMID 24451945
  4. [Expression of paxillin in breast cancer cell with high and low metastatic potentiality]. Cai H, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2010 Jan. PMID 20369478
  5. Binding of Paxillin to the alpha 9 Integrin Cytoplasmic Domain Inhibits Cell Spreading. Liu S, et al. J Biol Chem, 2001 Oct 5. PMID 11477105

See all (401) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
    Title: Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
  2. ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    Title: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
  3. Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
    Title: Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
  4. Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
    Title: Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
  5. Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
    Title: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
  6. Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
    Title: Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
  7. Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
    Title: Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
  8. Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
    Title: Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
  9. An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
    Title: An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
  10. Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Title: Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
Submit: New GeneRIF Correction See all GeneRIFs (183)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat HIV-1 Tat stimulates the phosphorylation of paxillin and its association with RAFTK, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma PubMed
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16691

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neuropilin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables vinculin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal complex assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
part_of microtubule associated complex TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
paxillin
Names
testicular tissue protein Li 134

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029820.1 RefSeqGene

    Range
    5042..60325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080855.3 → NP_001074324.1  paxillin isoform 2

    See identical proteins and their annotated locations for NP_001074324.1

    Status: REVIEWED

    Source sequence(s)
    BC144410, BU500419, BX648777, DB472926
    Consensus CDS
    CCDS44997.1
    UniProtKB/Swiss-Prot
    B2RAI3, B7ZMB4, O14970, O14971, O60360, P49023, Q5HYA4
    UniProtKB/TrEMBL
    A0A140VJQ8, B3KVL0
    Related
    ENSP00000228307.7, ENST00000228307.11
    Conserved Domains (5) summary
    cd09338
    Location:476 → 528
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:417 → 468
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:535 → 586
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:358 → 410
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  2. NM_001243756.2 → NP_001230685.1  paxillin isoform 3

    See identical proteins and their annotated locations for NP_001230685.1

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Consensus CDS
    CCDS58281.1
    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000267257.7, ENST00000267257.11
    Conserved Domains (5) summary
    cd09338
    Location:490 → 542
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:431 → 482
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:549 → 600
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:372 → 424
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  3. NM_001385981.1 → NP_001372910.1  paxillin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Consensus CDS
    CCDS91759.1
    UniProtKB/TrEMBL
    A0A1B0GTU4
    Related
    ENSP00000489840.1, ENST00000637617.2
    Conserved Domains (6) summary
    cd09338
    Location:966 → 1018
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:907 → 958
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1025 → 1076
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    PHA03247
    Location:314 → 606
    PHA03247; large tegument protein UL36; Provisional
    cd09336
    Location:848 → 900
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  4. NM_001385982.1 → NP_001372911.1  paxillin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Related
    ENSP00000554854.1, ENST00000884795.1
    Conserved Domains (5) summary
    cd09338
    Location:874 → 926
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:815 → 866
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:933 → 984
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:756 → 808
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  5. NM_001385983.1 → NP_001372912.1  paxillin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Related
    ENSP00000554861.1, ENST00000884802.1
    Conserved Domains (5) summary
    cd09338
    Location:872 → 924
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:813 → 864
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:931 → 982
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:754 → 806
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  6. NM_001385984.1 → NP_001372913.1  paxillin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Related
    ENSP00000637133.1, ENST00000967074.1
    Conserved Domains (6) summary
    cd09338
    Location:785 → 837
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:726 → 777
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:844 → 895
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    PHA03247
    Location:314 → 553
    PHA03247; large tegument protein UL36; Provisional
    cd09336
    Location:667 → 719
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  7. NM_001385985.1 → NP_001372914.1  paxillin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Related
    ENSP00000554858.1, ENST00000884799.1
    Conserved Domains (6) summary
    cd09338
    Location:737 → 789
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:678 → 729
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:796 → 847
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    PHA03247
    Location:314 → 553
    PHA03247; large tegument protein UL36; Provisional
    cd09336
    Location:619 → 671
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  8. NM_001385986.1 → NP_001372915.1  paxillin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Related
    ENSP00000586233.1, ENST00000916174.1
    Conserved Domains (6) summary
    cd09338
    Location:625 → 677
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:566 → 617
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:684 → 735
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    PHA03307
    Location:91 → 459
    PHA03307; transcriptional regulator ICP4; Provisional
    cd09336
    Location:507 → 559
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  9. NM_001385987.1 → NP_001372916.1  paxillin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004263
    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000554850.1, ENST00000884791.1
    Conserved Domains (5) summary
    cd09338
    Location:579 → 631
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:520 → 571
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:638 → 689
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:461 → 513
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  10. NM_001385988.1 → NP_001372917.1  paxillin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC004263
    UniProtKB/TrEMBL
    B3KVL0
    Conserved Domains (4) summary
    cd09407
    Location:465 → 516
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09336
    Location:406 → 458
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family
    cl02475
    Location:524 → 550
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  11. NM_001385989.1 → NP_001372918.1  paxillin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC004263
    UniProtKB/TrEMBL
    B3KVL0
    Conserved Domains (4) summary
    cd09407
    Location:415 → 466
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09336
    Location:356 → 408
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family
    cl02475
    Location:474 → 500
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  12. NM_001385990.1 → NP_001372919.1  paxillin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Conserved Domains (4) summary
    cd09407
    Location:383 → 434
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09336
    Location:324 → 376
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family
    cl02475
    Location:442 → 468
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  13. NM_001410986.1 → NP_001397915.1  paxillin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC004263
    Consensus CDS
    CCDS91758.1
    UniProtKB/TrEMBL
    B3KVL0, F5GZ78
    Related
    ENSP00000443887.1, ENST00000536957.5

  14. NM_002859.4 → NP_002850.2  paxillin isoform 1

    See identical proteins and their annotated locations for NP_002850.2

    Status: REVIEWED

    Source sequence(s)
    BC136794, BC144410, BU500419, BX648777, DB472926
    Consensus CDS
    CCDS44996.1
    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000391283.2, ENST00000424649.6
    Conserved Domains (5) summary
    cd09338
    Location:442 → 494
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:383 → 434
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:501 → 552
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:324 → 376
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  15. NM_025157.5 → NP_079433.3  paxillin isoform 4

    See identical proteins and their annotated locations for NP_079433.3

    Status: REVIEWED

    Source sequence(s)
    AC004263, BC136794, BC144410, BU500419, BX648777, DA565031
    Consensus CDS
    CCDS44998.1
    UniProtKB/Swiss-Prot
    P49023
    Related
    ENSP00000395536.2, ENST00000458477.6
    Conserved Domains (4) summary
    cd09338
    Location:309 → 361
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09336
    Location:191 → 243
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    cl02475
    Location:250 → 301
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam03535
    Location:1 → 120
    Paxillin; Paxillin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120210447..120265730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429246.1 → XP_047285202.1  paxillin isoform X15

    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000554849.1, ENST00000884790.1

  2. XM_047429241.1 → XP_047285197.1  paxillin isoform X9

    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000554856.1, ENST00000884797.1

  3. XM_047429240.1 → XP_047285196.1  paxillin isoform X8

    UniProtKB/TrEMBL
    B3KVL0
    Related
    ENSP00000554848.1, ENST00000884789.1

  4. XM_047429239.1 → XP_047285195.1  paxillin isoform X7

    Related
    ENSP00000586230.1, ENST00000916171.1

  5. XM_006719532.3 → XP_006719595.1  paxillin isoform X2

    Related
    ENSP00000637134.1, ENST00000967075.1
    Conserved Domains (5) summary
    cd09338
    Location:1014 → 1066
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:955 → 1006
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1073 → 1124
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:896 → 948
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  6. XM_011538622.2 → XP_011536924.1  paxillin isoform X3

    See identical proteins and their annotated locations for XP_011536924.1

    Conserved Domains (5) summary
    cd09338
    Location:881 → 933
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:822 → 873
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:940 → 991
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:763 → 815
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:1 → 120
    Paxillin; Paxillin family

  7. XM_047429236.1 → XP_047285192.1  paxillin isoform X1

  8. XM_047429250.1 → XP_047285206.1  paxillin isoform X19

    UniProtKB/TrEMBL
    B3KVL0

  9. XM_047429243.1 → XP_047285199.1  paxillin isoform X12

    UniProtKB/TrEMBL
    B3KVL0

  10. XM_047429249.1 → XP_047285205.1  paxillin isoform X18

    UniProtKB/TrEMBL
    B3KVL0

  11. XM_047429242.1 → XP_047285198.1  paxillin isoform X11

    UniProtKB/TrEMBL
    B3KVL0

  12. XM_047429244.1 → XP_047285200.1  paxillin isoform X14

    UniProtKB/TrEMBL
    B3KVL0

  13. XM_017019742.3 → XP_016875231.1  paxillin isoform X17

    UniProtKB/TrEMBL
    B3KVL0
    Conserved Domains (5) summary
    cd09338
    Location:448 → 500
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:389 → 440
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:507 → 558
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:330 → 382
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:60 → 259
    Paxillin; Paxillin family

  14. XM_017019739.3 → XP_016875228.1  paxillin isoform X10

    UniProtKB/TrEMBL
    B3KVL0
    Conserved Domains (5) summary
    cd09338
    Location:496 → 548
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:437 → 488
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:555 → 606
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:378 → 430
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:60 → 259
    Paxillin; Paxillin family

  15. XM_017019740.3 → XP_016875229.1  paxillin isoform X13

    UniProtKB/TrEMBL
    B3KVL0
    Conserved Domains (5) summary
    cd09338
    Location:482 → 534
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:423 → 474
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:541 → 592
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:364 → 416
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:60 → 259
    Paxillin; Paxillin family

  16. XM_047429252.1 → XP_047285208.1  paxillin isoform X21

  17. XM_047429253.1 → XP_047285209.1  paxillin isoform X22

  18. XM_047429251.1 → XP_047285207.1  paxillin isoform X20

  19. XM_047429238.1 → XP_047285194.1  paxillin isoform X6

  20. XM_047429237.1 → XP_047285193.1  paxillin isoform X5

  21. XM_047429248.1 → XP_047285204.1  paxillin isoform X16

  22. XM_017019732.3 → XP_016875221.2  paxillin isoform X4

RNA

  1. XR_002957365.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120197626..120252894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372755.1 → XP_054228730.1  paxillin isoform X15

    UniProtKB/TrEMBL
    B3KVL0

  2. XM_054372748.1 → XP_054228723.1  paxillin isoform X9

    UniProtKB/TrEMBL
    B3KVL0

  3. XM_054372747.1 → XP_054228722.1  paxillin isoform X8

    UniProtKB/TrEMBL
    B3KVL0

  4. XM_054372741.1 → XP_054228716.1  paxillin isoform X7

  5. XM_054372732.1 → XP_054228707.1  paxillin isoform X2

  6. XM_054372735.1 → XP_054228710.1  paxillin isoform X3

  7. XM_054372730.1 → XP_054228705.1  paxillin isoform X1

  8. XM_054372758.1 → XP_054228733.1  paxillin isoform X19

    UniProtKB/TrEMBL
    B3KVL0

  9. XM_054372751.1 → XP_054228726.1  paxillin isoform X12

    UniProtKB/TrEMBL
    B3KVL0

  10. XM_054372733.1 → XP_054228708.1  paxillin isoform X24

  11. XM_054372757.1 → XP_054228732.1  paxillin isoform X18

    UniProtKB/TrEMBL
    B3KVL0

  12. XM_054372750.1 → XP_054228725.1  paxillin isoform X11

    UniProtKB/TrEMBL
    B3KVL0

  13. XM_054372754.1 → XP_054228729.1  paxillin isoform X14

    UniProtKB/TrEMBL
    B3KVL0

  14. XM_054372746.1 → XP_054228721.1  paxillin isoform X35

    UniProtKB/TrEMBL
    B3KVL0

  15. XM_054372743.1 → XP_054228718.1  paxillin isoform X32

    UniProtKB/TrEMBL
    B3KVL0

  16. XM_054372731.1 → XP_054228706.1  paxillin isoform X23

  17. XM_054372756.1 → XP_054228731.1  paxillin isoform X17

    UniProtKB/TrEMBL
    B3KVL0

  18. XM_054372749.1 → XP_054228724.1  paxillin isoform X10

    UniProtKB/TrEMBL
    B3KVL0

  19. XM_054372753.1 → XP_054228728.1  paxillin isoform X36

    UniProtKB/TrEMBL
    B3KVL0

  20. XM_054372745.1 → XP_054228720.1  paxillin isoform X34

    UniProtKB/TrEMBL
    B3KVL0

  21. XM_054372752.1 → XP_054228727.1  paxillin isoform X13

    UniProtKB/TrEMBL
    B3KVL0

  22. XM_054372744.1 → XP_054228719.1  paxillin isoform X33

    UniProtKB/TrEMBL
    B3KVL0

  23. XM_054372742.1 → XP_054228717.1  paxillin isoform X31

    UniProtKB/TrEMBL
    B3KVL0

  24. XM_054372740.1 → XP_054228715.1  paxillin isoform X30

  25. XM_054372739.1 → XP_054228714.1  paxillin isoform X29

  26. XM_054372738.1 → XP_054228713.1  paxillin isoform X28

  27. XM_054372737.1 → XP_054228712.1  paxillin isoform X27

  28. XM_054372734.1 → XP_054228709.1  paxillin isoform X25

  29. XM_054372736.1 → XP_054228711.1  paxillin isoform X26

RNA

  1. XR_008488651.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49023.3 GenPept UniProtKB/Swiss-Prot:P49023

Gene LinkOut

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