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Mpst mercaptopyruvate sulfurtransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 192172, updated on 13-Apr-2024

Summary

Symbol
Mpstprovided by RGD
Full Name
mercaptopyruvate sulfurtransferaseprovided by RGD
Primary source
RGD:620065
See related
Ensembl:ENSRNOG00000000185 AllianceGenome:RGD:620065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mst
Summary
Enables identical protein binding activity and thiosulfate sulfurtransferase activity. Involved in animal organ development and transsulfuration. Located in cytosol and mitochondrion. Biomarker of type 2 diabetes mellitus. Orthologous to human MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 572.5), Liver (RPKM 385.4) and 9 other tissues See more
Orthologs
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Genomic context

Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111836079..111843651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109955581..109963155)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119626636..119631317)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 4 Neighboring gene uncharacterized LOC120093821 Neighboring gene thiosulfate sulfurtransferase Neighboring gene uncharacterized LOC120093822 Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene transmembrane serine protease 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3-mercaptopyruvate sulfurtransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiosulfate sulfurtransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in hydrogen sulfide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen sulfide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in kidney development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in liver development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transsulfuration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-mercaptopyruvate sulfurtransferase
NP_620198.1
XP_038934288.1
XP_063119029.1
XP_063119030.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138843.2NP_620198.1  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_620198.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P97532
    UniProtKB/TrEMBL
    A6HSJ8
    Related
    ENSRNOP00000000201.2, ENSRNOT00000000201.6
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    111836079..111843651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078360.2XP_038934288.1  3-mercaptopyruvate sulfurtransferase isoform X2

    UniProtKB/TrEMBL
    A6HSJ9
    Conserved Domains (1) summary
    cd01448
    Location:10139
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
  2. XM_063262959.1XP_063119029.1  3-mercaptopyruvate sulfurtransferase isoform X1

    UniProtKB/Swiss-Prot
    P97532
    UniProtKB/TrEMBL
    A6HSJ8
  3. XM_063262960.1XP_063119030.1  3-mercaptopyruvate sulfurtransferase isoform X1

    UniProtKB/Swiss-Prot
    P97532
    UniProtKB/TrEMBL
    A6HSJ8