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Mpst mercaptopyruvate sulfurtransferase [ Mus musculus (house mouse) ]

Gene ID: 246221, updated on 10-Mar-2023

Summary

Official Symbol
Mpstprovided by MGI
Official Full Name
mercaptopyruvate sulfurtransferaseprovided by MGI
Primary source
MGI:MGI:2179733
See related
Ensembl:ENSMUSG00000071711 AllianceGenome:MGI:2179733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst
Summary
Enables 3-mercaptopyruvate sulfurtransferase activity. Involved in hydrogen sulfide biosynthetic process. Located in neuron projection. Orthologous to human MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 106.7), stomach adult (RPKM 95.9) and 27 other tissues See more
Orthologs
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Genomic context

See Mpst in Genome Data Viewer
Location:
15; 15 E1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78290912..78298215)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78406712..78414015)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene testis expressed 33 Neighboring gene thiosulfate sulfurtransferase, mitochondrial Neighboring gene predicted gene, 52185 Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355 Neighboring gene potassium channel tetramerisation domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-mercaptopyruvate sulfurtransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiosulfate sulfurtransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in hydrogen sulfide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in transsulfuration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-mercaptopyruvate sulfurtransferase
NP_001155964.1
NP_001155965.1
NP_619611.3
XP_006521057.1
XP_006521058.1
XP_006521059.1
XP_036015306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162492.2NP_001155964.1  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_001155964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q505N7
    UniProtKB/TrEMBL
    Q3UW66
    Related
    ENSMUSP00000128075.2, ENSMUST00000169133.8
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  2. NM_001162493.2NP_001155965.1  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_001155965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q505N7
    UniProtKB/TrEMBL
    Q3UW66
    Related
    ENSMUSP00000130493.2, ENSMUST00000167140.8
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  3. NM_001416057.1NP_001402986.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q505N7
  4. NM_001416058.1NP_001402987.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q505N7
  5. NM_001416059.1NP_001402988.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q505N7
  6. NM_001416060.1NP_001402989.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q505N7
  7. NM_001416061.1NP_001402990.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q505N7
  8. NM_138670.4NP_619611.3  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_619611.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q505N7
    UniProtKB/TrEMBL
    Q3UW66
    Related
    ENSMUSP00000043061.7, ENSMUST00000043865.8
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78290912..78298215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520994.5XP_006521057.1  3-mercaptopyruvate sulfurtransferase isoform X1

    UniProtKB/TrEMBL
    Q3UW66
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  2. XM_006520996.5XP_006521059.1  3-mercaptopyruvate sulfurtransferase isoform X1

    UniProtKB/TrEMBL
    Q3UW66
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  3. XM_036159413.1XP_036015306.1  3-mercaptopyruvate sulfurtransferase isoform X1

    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  4. XM_006520995.4XP_006521058.1  3-mercaptopyruvate sulfurtransferase isoform X1

    UniProtKB/TrEMBL
    Q3UW66
    Conserved Domains (1) summary
    COG2897
    Location:1279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]