Format

Send to:

Choose Destination

MPST mercaptopyruvate sulfurtransferase [ Homo sapiens (human) ]

Gene ID: 4357, updated on 5-Aug-2018

Summary

Official Symbol
MPSTprovided by HGNC
Official Full Name
mercaptopyruvate sulfurtransferaseprovided by HGNC
Primary source
HGNC:HGNC:7223
See related
Ensembl:ENSG00000128309 MIM:602496; Vega:OTTHUMG00000150543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; TST2; TUM1
Summary
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 33.5), liver (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See MPST in Genome Data Viewer
Location:
22q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37019642..37029822)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37415683..37425863)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ39582-like Neighboring gene testis expressed 33 Neighboring gene thiosulfate sulfurtransferase Neighboring gene uncharacterized LOC112268295 Neighboring gene RNA, 7SK small nuclear pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Amino Acid metabolism, organism-specific biosystem (from WikiPathways)
    Amino Acid metabolism, organism-specific biosystemA complete overview of the metabolism of all 20 amino acids
  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Sulfur metabolism, organism-specific biosystem (from KEGG)
    Sulfur metabolism, organism-specific biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur metabolism, conserved biosystem (from KEGG)
    Sulfur metabolism, conserved biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur relay system, organism-specific biosystem (from KEGG)
    Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • Sulfur relay system, conserved biosystem (from KEGG)
    Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • Trans-sulfuration pathway, organism-specific biosystem (from WikiPathways)
    Trans-sulfuration pathway, organism-specific biosystemTrans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24539

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-mercaptopyruvate sulfurtransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
3-mercaptopyruvate sulfurtransferase activity TAS
Traceable Author Statement
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
thiosulfate sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cyanate catabolic process TAS
Traceable Author Statement
more info
PubMed 
hydrogen sulfide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
 
transsulfuration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-mercaptopyruvate sulfurtransferase
Names
human liver rhodanese
tRNA thiouridin modification protein 1
testicular tissue protein Li 200
NP_001013454.1
NP_001123989.1
NP_066949.2
XP_005261667.1
XP_011528497.1
XP_011528498.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013436.2NP_001013454.1  3-mercaptopyruvate sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001013454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the first exon compared to variant 1, resulting in translation initiation from a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1. Transcript variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC016737, BI463699, CX866643, X59434
    Consensus CDS
    CCDS13939.1
    UniProtKB/Swiss-Prot
    P25325
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000384812.3, OTTHUMP00000197787, ENST00000401419.7, OTTHUMT00000318828
    Conserved Domains (3) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01448
    Location:10139
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cd01449
    Location:164279
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.
  2. NM_001130517.2NP_001123989.1  3-mercaptopyruvate sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001123989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site at the first exon and contains an additional 5' non-coding exon compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1. Transcript variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC003508, BI463699, BX406051, X59434
    Consensus CDS
    CCDS13939.1
    UniProtKB/Swiss-Prot
    P25325
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000383950.3, OTTHUMP00000197789, ENST00000404802.7, OTTHUMT00000318830
    Conserved Domains (3) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01448
    Location:10139
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cd01449
    Location:164279
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.
  3. NM_021126.5NP_066949.2  3-mercaptopyruvate sulfurtransferase isoform 1

    See identical proteins and their annotated locations for NP_066949.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC016737, BI597227, X59434
    Consensus CDS
    CCDS46703.1
    UniProtKB/Swiss-Prot
    P25325
    Related
    ENSP00000411719.3, OTTHUMP00000197786, ENST00000429360.5, OTTHUMT00000318827
    Conserved Domains (3) summary
    PLN02723
    Location:6299
    PLN02723; 3-mercaptopyruvate sulfurtransferase
    cd01448
    Location:30159
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cd01449
    Location:184299
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37019642..37029822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261610.3XP_005261667.1  3-mercaptopyruvate sulfurtransferase isoform X1

    See identical proteins and their annotated locations for XP_005261667.1

    UniProtKB/Swiss-Prot
    P25325
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000342333.3, OTTHUMP00000197788, ENST00000341116.7, OTTHUMT00000318829
    Conserved Domains (3) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01448
    Location:10139
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cd01449
    Location:164279
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.
  2. XM_011530195.1XP_011528497.1  3-mercaptopyruvate sulfurtransferase isoform X2

    Conserved Domains (4) summary
    COG2897
    Location:16219
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01448
    Location:30159
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    pfam13900
    Location:219237
    GVQW; Putative domain of unknown function
    cl00125
    Location:184217
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  3. XM_011530196.1XP_011528498.1  3-mercaptopyruvate sulfurtransferase isoform X3

    Conserved Domains (3) summary
    COG2897
    Location:10202
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01448
    Location:10139
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cl00125
    Location:164199
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013440.1: Suppressed sequence

    Description
    NM_001013440.1: This RefSeq was permanently suppressed because it was annotated to initiate translation from a downstream AUG when an upstream AUG exists, initiation from which will render this RefSeq susceptible to nonsense-mediated mRNA decay (NMD).
  2. NR_024038.1: Suppressed sequence

    Description
    NR_024038.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Support Center