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Prkg2 protein kinase, cGMP-dependent, type II [ Mus musculus (house mouse) ]

Gene ID: 19092, updated on 11-Apr-2024

Summary

Official Symbol
Prkg2provided by MGI
Official Full Name
protein kinase, cGMP-dependent, type IIprovided by MGI
Primary source
MGI:MGI:108173
See related
Ensembl:ENSMUSG00000029334 AllianceGenome:MGI:108173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGKII; Prkgr2; cGK-II
Summary
Predicted to enable cGMP-dependent protein kinase activity and identical protein binding activity. Involved in cellular hypotonic response and negative regulation of cell volume. Acts upstream of or within circadian regulation of gene expression. Located in plasma membrane. Is expressed in brain; limb segment; lung; and small intestine. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 2.2), frontal lobe adult (RPKM 1.5) and 16 other tissues See more
Orthologs
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Genomic context

Location:
5 E3; 5 48.35 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (99077632..99185042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (98929773..99037375, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Bmp3 5' regulatory region Neighboring gene predicted gene, 34563 Neighboring gene bone morphogenetic protein 3 Neighboring gene predicted gene, 42123 Neighboring gene STARR-seq mESC enhancer starr_13704 Neighboring gene STARR-seq mESC enhancer starr_13705 Neighboring gene predicted gene 3470 Neighboring gene predicted gene, 19873 Neighboring gene RasGEF domain family, member 1B Neighboring gene STARR-positive B cell enhancer ABC_E6350

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Clone Names

  • MGC130517

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
 
enables cGMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-dependent protein kinase 2
Names
cGK 2
cGK2
cGMP-dependent protein kinase II
NP_032952.3
XP_006534883.1
XP_006534884.1
XP_036020790.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008926.4NP_032952.3  cGMP-dependent protein kinase 2

    See identical proteins and their annotated locations for NP_032952.3

    Status: VALIDATED

    Source sequence(s)
    AC141896, AK038739, AK081422
    Consensus CDS
    CCDS19459.1
    UniProtKB/TrEMBL
    Q8C4R2, Q8CAH8
    Related
    ENSMUSP00000124963.2, ENSMUST00000161490.8
    Conserved Domains (4) summary
    PTZ00263
    Location:417752
    PTZ00263; protein kinase A catalytic subunit; Provisional
    COG0664
    Location:162285
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:286401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:459718
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    99077632..99185042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164897.1XP_036020790.1  cGMP-dependent protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q8C4R2
    Conserved Domains (2) summary
    cd00038
    Location:286401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:459718
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
  2. XM_006534821.3XP_006534884.1  cGMP-dependent protein kinase 2 isoform X3

    Conserved Domains (1) summary
    cd05572
    Location:1238
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
  3. XM_006534820.5XP_006534883.1  cGMP-dependent protein kinase 2 isoform X2

    Conserved Domains (2) summary
    cd00038
    Location:286401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam08614
    Location:2484
    ATG16; Autophagy protein 16 (ATG16)