Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 1996 Dec 20;274(5295):2082-6.

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.

Author information

  • 1Institut f-ur Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 M-unchen, Germany. pfeifer@ipt.med.tu-muenchen.de

Abstract

Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

PMID:
8953039
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center