Format

Send to:

Choose Destination

Plg plasminogen [ Mus musculus (house mouse) ]

Gene ID: 18815, updated on 14-May-2019

Summary

Official Symbol
Plgprovided by MGI
Official Full Name
plasminogenprovided by MGI
Primary source
MGI:MGI:97620
See related
Ensembl:ENSMUSG00000059481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pg; AI649309
Expression
Biased expression in liver E18 (RPKM 538.8), liver adult (RPKM 533.8) and 3 other tissues See more
Orthologs

Genomic context

See Plg in Genome Data Viewer
Location:
17 A1; 17 8.5 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (12378609..12419384)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12571475..12612250)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 3 pseudogene Neighboring gene predicted gene, 41527 Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene RIKEN cDNA C030013G03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteasome core complex binding ISO
Inferred from Sequence Orthology
more info
 
protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
interaction with symbiont ISO
Inferred from Sequence Orthology
more info
 
interaction with symbiont via secreted substance involved in symbiotic interaction ISO
Inferred from Sequence Orthology
more info
 
labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
modification by host of symbiont morphology or physiology via secreted substance ISO
Inferred from Sequence Orthology
more info
 
mononuclear cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
trans-synaptic signaling by BDNF, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix HDA PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
other organism cell membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasminogen
Names
angiostatin
plasmin heavy chain A
plasmin light chain B
NP_032903.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008877.3NP_032903.3  plasminogen precursor

    See identical proteins and their annotated locations for NP_032903.3

    Status: VALIDATED

    Source sequence(s)
    AK132254, BY131661, J04766
    Consensus CDS
    CCDS28390.1
    UniProtKB/Swiss-Prot
    P20918
    UniProtKB/TrEMBL
    Q3V1T9
    Related
    ENSMUSP00000014578.5, ENSMUST00000014578.6
    Conserved Domains (4) summary
    smart00020
    Location:581805
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:273354
    KR; Kringle domain
    cd00190
    Location:582807
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01099
    Location:3897
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    12378609..12419384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center