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Plat plasminogen activator, tissue [ Mus musculus (house mouse) ]

Gene ID: 18791, updated on 18-Jun-2019

Summary

Official Symbol
Platprovided by MGI
Official Full Name
plasminogen activator, tissueprovided by MGI
Primary source
MGI:MGI:97610
See related
Ensembl:ENSMUSG00000031538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tPA; AU020998; AW212668; D8Ertd2e
Summary
This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]
Expression
Broad expression in ovary adult (RPKM 44.8), subcutaneous fat pad adult (RPKM 41.2) and 20 other tissues See more
Orthologs

Genomic context

See Plat in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (22757722..22782848)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23868216..23893320)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene polymerase (DNA directed), beta Neighboring gene inhibitor of kappaB kinase beta Neighboring gene adaptor-related protein complex 3, mu 2 subunit Neighboring gene predicted gene, 46036 Neighboring gene K(lysine) acetyltransferase 6A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC18508

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ovulation ISO
Inferred from Sequence Orthology
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
trans-synaptic signaling by BDNF, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 
perisynaptic space ISO
Inferred from Sequence Orthology
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tissue-type plasminogen activator
Names
t-plasminogen activator
NP_032898.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008872.3NP_032898.2  tissue-type plasminogen activator preproprotein

    See identical proteins and their annotated locations for NP_032898.2

    Status: REVIEWED

    Source sequence(s)
    AC121835, AK135965, CJ146601, DV644940
    Consensus CDS
    CCDS22183.1
    UniProtKB/Swiss-Prot
    P11214
    Related
    ENSMUSP00000033941.5, ENSMUST00000033941.6
    Conserved Domains (5) summary
    smart00020
    Location:308553
    Tryp_SPc; Trypsin-like serine protease
    smart00058
    Location:3880
    FN1; Fibronectin type 1 domain
    cd00108
    Location:210295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:311556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:124205
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    22757722..22782848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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