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Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) [ Mus musculus (house mouse) ]

Gene ID: 18783, updated on 12-May-2024

Summary

Official Symbol
Pla2g4aprovided by MGI
Official Full Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)provided by MGI
Primary source
MGI:MGI:1195256
See related
Ensembl:ENSMUSG00000056220 AllianceGenome:MGI:1195256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cPLA2; Pla2g4; cPLA2alpha; cPLA2-alpha
Summary
The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid. Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play important roles in regulating diverse biological processes such as inflammatory responses, membrane and actin dynamics, and tumorigenesis. A rise in intracellular calcium levels results in binding of calcium to the C2 domain of this protein, and triggers the translocation from the cytosol to intracellular membranes, including the Golgi apparatus. Disruption of this gene in mice led to decreased levels of eicosonaoids and platelet-activating factor, decreased allergic symptoms, and impaired reproductive ability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Expression
Biased expression in bladder adult (RPKM 17.0), placenta adult (RPKM 4.1) and 12 other tissues See more
Orthologs
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Genomic context

See Pla2g4a in Genome Data Viewer
Location:
1 G1; 1 63.51 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (149705369..149837041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (149829618..149961290, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 29398 Neighboring gene STARR-seq mESC enhancer starr_02583 Neighboring gene STARR-seq mESC enhancer starr_02584 Neighboring gene STARR-seq mESC enhancer starr_02585 Neighboring gene STARR-seq mESC enhancer starr_02586 Neighboring gene predicted gene, 23535 Neighboring gene STARR-seq mESC enhancer starr_02587 Neighboring gene STARR-seq mESC enhancer starr_02588 Neighboring gene STARR-seq mESC enhancer starr_02589 Neighboring gene STARR-seq mESC enhancer starr_02590 Neighboring gene STARR-seq mESC enhancer starr_02591 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02592 Neighboring gene STARR-seq mESC enhancer starr_02593 Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables ceramide 1-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within arachidonic acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to antibiotic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within icosanoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in monoacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation from ovarian follicle ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activating factor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2
Names
Cytosolic phospholipase A2 (CPLA2)
Type IV PLA2
cytosolic PLA2
phospholipase A2 group IVA
phospholipase A2, group 4
NP_001292561.1
NP_032895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305632.1NP_001292561.1  cytosolic phospholipase A2 isoform 2

    See identical proteins and their annotated locations for NP_001292561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK004701, BQ033204
    Consensus CDS
    CCDS78700.1
    UniProtKB/TrEMBL
    Q9DBX5
    Related
    ENSMUSP00000107557.3, ENSMUST00000111926.9
    Conserved Domains (3) summary
    cd07200
    Location:136721
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:12130
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:109660
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
  2. NM_008869.4NP_032895.1  cytosolic phospholipase A2 isoform 1

    See identical proteins and their annotated locations for NP_032895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158151, BQ033204, M72394
    Consensus CDS
    CCDS15352.1
    UniProtKB/Swiss-Prot
    P47713
    UniProtKB/TrEMBL
    Q3UMQ1
    Related
    ENSMUSP00000070868.9, ENSMUST00000070200.15
    Conserved Domains (2) summary
    cd07200
    Location:144729
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:20138
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    149705369..149837041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)