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PLA2G4A phospholipase A2 group IVA [ Homo sapiens (human) ]

Gene ID: 5321, updated on 11-Jun-2021

Summary

Official Symbol
PLA2G4Aprovided by HGNC
Official Full Name
phospholipase A2 group IVAprovided by HGNC
Primary source
HGNC:HGNC:9035
See related
Ensembl:ENSG00000116711 MIM:600522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GURDP; cPLA2; PLA2G4; cPLA2-alpha
Summary
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 6.0), adrenal (RPKM 5.6) and 24 other tissues See more
Orthologs
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Genomic context

See PLA2G4A in Genome Data Viewer
Location:
1q31.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (186828949..186988981)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186798081..186958113)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PTGS2 antisense NFKB1 complex-mediated expression regulator RNA Neighboring gene prostaglandin-endoperoxide synthase 2 Neighboring gene long intergenic non-protein coding RNA 1036 Neighboring gene uncharacterized LOC105371655 Neighboring gene long intergenic non-protein coding RNA 1037

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder
MedGen: C5193061 OMIM: 618372 GeneReviews: Not available
Compare labs
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
GeneReviews: Not available
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase A2, group IVA (PLA2G4A) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide 1-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity NAS
Non-traceable Author Statement
more info
PubMed 
enables phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiolipin acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in cellular response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in icosanoid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 
involved_in platelet activating factor biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytosolic phospholipase A2
Names
calcium-dependent phospholipid-binding protein
lysophospholipase
phosphatidylcholine 2-acylhydrolase
phospholipase A2, group IVA (cytosolic, calcium-dependent)
NP_001298122.2
NP_077734.2
XP_005245324.2
XP_011507944.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012203.2 RefSeqGene

    Range
    5050..165082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_596

mRNA and Protein(s)

  1. NM_001311193.2NP_001298122.2  cytosolic phospholipase A2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL022147, AL049797
    Conserved Domains (2) summary
    cd07200
    Location:114670
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:20129
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
  2. NM_024420.3NP_077734.2  cytosolic phospholipase A2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049797, BC114340, BX118890, DA451491, M72393
    Consensus CDS
    CCDS1372.1
    Related
    ENSP00000356436.3, ENST00000367466.4
    Conserved Domains (2) summary
    cd07200
    Location:144730
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:20138
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    186828949..186988981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509642.2XP_011507944.1  cytosolic phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011507944.1

    UniProtKB/Swiss-Prot
    P47712
    Conserved Domains (2) summary
    cd07200
    Location:144730
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:20138
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
  2. XM_005245267.4XP_005245324.2  cytosolic phospholipase A2 isoform X1

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