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Pla2r1 phospholipase A2 receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 18779, updated on 9-May-2024

Summary

Official Symbol
Pla2r1provided by MGI
Official Full Name
phospholipase A2 receptor 1provided by MGI
Primary source
MGI:MGI:102468
See related
Ensembl:ENSMUSG00000054580 AllianceGenome:MGI:102468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pla2r; Pla2-r; Pla2g1br
Summary
Enables phospholipase binding activity. Involved in negative regulation of phospholipase A2 activity; receptor-mediated endocytosis; and regulation of arachidonic acid secretion. Located in extracellular region. Is expressed in central nervous system and sensory organ. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 10.8), lung adult (RPKM 2.6) and 7 other tissues See more
Orthologs
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Genomic context

See Pla2r1 in Genome Data Viewer
Location:
2 C1.1; 2 34.65 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60247887..60383669, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60417543..60553326, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 75 Neighboring gene predicted gene 13571 Neighboring gene STARR-seq mESC enhancer starr_04613 Neighboring gene predicted gene 13580 Neighboring gene STARR-seq mESC enhancer starr_04614 Neighboring gene STARR-seq mESC enhancer starr_04615 Neighboring gene predicted gene 13583 Neighboring gene TBC1 domain family, member 15 pseudogene Neighboring gene 40S ribosomal protein S21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
secretory phospholipase A2 receptor
Names
180 kDa secretory phospholipase A2 receptor
M-type receptor
PLA2-I receptor
phospholipase A2, group IB, pancreas, receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008867.2NP_032893.1  secretory phospholipase A2 receptor precursor

    See identical proteins and their annotated locations for NP_032893.1

    Status: VALIDATED

    Source sequence(s)
    AK036808, BC141356, BX679662, BY772059
    Consensus CDS
    CCDS16059.1
    UniProtKB/Swiss-Prot
    A2AS64, B9EJ68, Q62028, Q80ZL5
    Related
    ENSMUSP00000108144.4, ENSMUST00000112525.5
    Conserved Domains (5) summary
    cd00037
    Location:245358
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:380504
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:47154
    RICIN; Ricin-type beta-trefoil
    cd00062
    Location:175222
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00161
    Location:55123
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    60247887..60383669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498928.5XP_006498991.1  secretory phospholipase A2 receptor isoform X1

    Conserved Domains (3) summary
    cd00037
    Location:153266
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:288412
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cd00062
    Location:83130
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...